Adiponectin in umbillcal cord blood is inversely related to low-density lipoprotein cholesteril but not ethnicity

Bansal, Narinder, Charlton-Menys, Valentine, Pemberton, Philip, McElduff, Patrick, Oldroyd, John Charles, Vyas, Avni, Koudsi, Abir, Clayton, Peter E., Cruickshank, J. Kennedy and Durrington, Paul N. 2006, Adiponectin in umbillcal cord blood is inversely related to low-density lipoprotein cholesteril but not ethnicity, Journal of clinical endorinology and metabolism, vol. 91, no. 6, pp. 2244-2249, doi: 10.1210/jc.2005-2714.

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Title Adiponectin in umbillcal cord blood is inversely related to low-density lipoprotein cholesteril but not ethnicity
Author(s) Bansal, Narinder
Charlton-Menys, Valentine
Pemberton, Philip
McElduff, Patrick
Oldroyd, John Charles
Vyas, Avni
Koudsi, Abir
Clayton, Peter E.
Cruickshank, J. KennedyORCID iD for Cruickshank, J. Kennedy
Durrington, Paul N.
Journal name Journal of clinical endorinology and metabolism
Volume number 91
Issue number 6
Start page 2244
End page 2249
Publisher J. B. Lippincott
Place of publication Philadelphia, PA
Publication date 2006
ISSN 0021-972X
Summary Context: Adiponectin is a recognized protective risk marker for cardiovascular disease in adults and is associated with an optimal lipid profile. The role of adiponectin at birth is not well understood, and its relationship with the neonatal lipid profile is unknown. Because ethnic disparities in cardiovascular risk have been attributed to low adiponectin and its associated low high-density lipoprotein cholesterol (HDL-C), investigation at birth may help determine the etiology of these risk patterns.

Objective: Our objective was to investigate the relationship between neonatal adiponectin and lipid profile at birth in two ethnic groups in cord blood.

Design, Setting, and Participants: Seventy-four healthy mothers and their newborns of South Asian and White European origin were studied in this cross-sectional study at St. Mary’s Hospital, Manchester, United Kingdom.

Main Outcome Measures: Serum adiponectin, total cholesterol, HDL-C, low-density lipoprotein cholesterol (LDL-C), and triglyceride levels were measured in umbilical venous blood at birth and in maternal blood collected at 28 wk gestation.

Results: Cord adiponectin was significantly inversely associated with cord LDL-C (r = –0.32; P = 0.005) but not HDL-C. In a multiple regression analysis, cord LDL-C remained the most significant association of cord adiponectin (ß = –0.13; P < 0.001). We did not find any significant ethnic differences in cord adiponectin or lipids with the exception of triglycerides, which were significantly lower in South Asian newborns (P < 0.05).

Conclusion: This is the first report of an inverse relationship between cord adiponectin and LDL-C at birth. In contrast to adult studies, we found no significant association between adiponectin and HDL-C in cord blood. Our results and the strong independent association between adiponectin and HDL-C observed in adult studies suggest a role for adiponectin in lipid metabolism. Ethnic differences in adiponectin may arise after birth.
Language eng
DOI 10.1210/jc.2005-2714
Field of Research 110202 Haematology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, The Endocrine Society
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Document type: Journal Article
Collection: School of Health and Social Development
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