Validity of the assessment of quality of life (AQoL) utility instrument in patients with operable and inoperable lung cancer

Manser, Renee L., Wright, Gavin, Byrnes, Graham, Hart, David, Conron, Matthew, Carter, Rob, McLachlan, Sue-Anne and Campbell, Donald A. 2006, Validity of the assessment of quality of life (AQoL) utility instrument in patients with operable and inoperable lung cancer, Lung cancer, vol. 53, no. 2, pp. 217-229.

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Title Validity of the assessment of quality of life (AQoL) utility instrument in patients with operable and inoperable lung cancer
Author(s) Manser, Renee L.
Wright, Gavin
Byrnes, Graham
Hart, David
Conron, Matthew
Carter, Rob
McLachlan, Sue-Anne
Campbell, Donald A.
Journal name Lung cancer
Volume number 53
Issue number 2
Start page 217
End page 229
Publisher Elsevier Ireland Ltd.
Place of publication Ireland
Publication date 2006-08
ISSN 0169-5002
1872-8332
Keyword(s) lung cancer
quality of life
utility
multi-attribute utility instrument
cost-utility
questionnaire
non-small cell lung cancer
Summary There have been few longitudinal studies of quality of life in patients with all stages of lung cancer, particularly those that have included measures of utility. The purpose of this study was to examine the psychometric properties of the Assessment of Quality of Life instrument (AQoL) in patients with lung cancer. The AQoL is a health-related quality of life questionnaire and provides a descriptive system for a multi-attribute utility instrument (MAU), so that scores can be used in cost-utility evaluations. In the present study the reliability (internal consistency) of the AQoL was examined and the concurrent validity was assessed using the Medical Outcomes 36-item Short Form Health Survey (SF-36) as the comparator instrument. The sensitivity to different health states of the AQoL and the responsiveness to change over time was also examined. A prospective, non-experimental cohort study was undertaken. Ninety-two participants with all stages of lung cancer were recruited from a tertiary multi-disciplinary lung cancer clinic. Ninety participants had non-small cell lung cancer (NSCLC) and two had limited stage small cell lung cancer. The AQOL and SF-36 surveys were administered concurrently at baseline. In patients with NSCLC the surveys were then repeated 3 and 6 months later. Correlations between the baseline AQoL summary scales and SF-36 summary scales support the divergent and convergent validity of the AQoL. Reliability was also found to be sufficient (Cronbach's Alpha = 0.76). In addition, in patients with inoperable NSCLC, baseline AQoL scores were found to be predictive of survival at 6 months in Cox proportional hazards multivariate analysis. However, the physical components summary score of the SF-36 was more sensitive to differences in health states between patients with different stages of NSCLC at 6 months of follow-up and more responsive to change over time in both operable and inoperable patients with NSCLC than the AQoL. The findings support the construct validity and reliability of the AQoL in this population. However, there remains some uncertainty about whether the AQoL has sufficient sensitivity to different health states in this population. Further studies using other MAU instruments may determine whether alternative instruments are more sensitive to different health states in individuals with lung cancer.
Notes Available online 12 June 2006.
Language eng
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Elsevier Ireland Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009315

Document type: Journal Article
Collection: School of Health and Social Development
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