Hepatitis B Virus transmission and hepatocarcinogenesis: a 9 year retropective cohort of 13676 relatives with hepatocellular carcinoma

Chen, Chien-Hung, Chen, Yang Yuan, Chen, Gran-Hum, Yang, Sien-Sing, Tang, Huang-Shang, Lin, Hsien Hong, Lin, Deng-Yn, Lo, Sing Kai, Du, Jeng-Ming, Chang, Ting-Tsung, Chen, Shinn-Cherng, Liao, Li-Ying, Kuo, Chung-Huang, Lin, Kwo-Chuan, Tai, Dar-In, Changchien, Chi-Sin, Chang, Wen-Yu, Sheu, Jin-Chuan, Chen, Ding-Shinn, Liaw, Yun-Fan and Sung, Juei-Low 2004, Hepatitis B Virus transmission and hepatocarcinogenesis: a 9 year retropective cohort of 13676 relatives with hepatocellular carcinoma, Journal of hepatology, vol. 40, no. 4, pp. 653-659.

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Title Hepatitis B Virus transmission and hepatocarcinogenesis: a 9 year retropective cohort of 13676 relatives with hepatocellular carcinoma
Author(s) Chen, Chien-Hung
Chen, Yang Yuan
Chen, Gran-Hum
Yang, Sien-Sing
Tang, Huang-Shang
Lin, Hsien Hong
Lin, Deng-Yn
Lo, Sing Kai
Du, Jeng-Ming
Chang, Ting-Tsung
Chen, Shinn-Cherng
Liao, Li-Ying
Kuo, Chung-Huang
Lin, Kwo-Chuan
Tai, Dar-In
Changchien, Chi-Sin
Chang, Wen-Yu
Sheu, Jin-Chuan
Chen, Ding-Shinn
Liaw, Yun-Fan
Sung, Juei-Low
Journal name Journal of hepatology
Volume number 40
Issue number 4
Start page 653
End page 659
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2004-04
ISSN 0168-8278
Keyword(s) maternal–fetal exchange
Taiwan
survival analysis
hepatitis B surface antigen
family HBsAg, hepatitis B surface antigen
HBV, hepatitis B virus
HCC, hepatocellular carcinoma
MP, HBsAg positive mother
MN, HBsAg negative mother
FP, HBsAg positive father
FN, HBsAg negative father
Summary Background/Aims
Familial clustering of hepatitis B virus (HBV) infection is related to perinatal transmission, and is the main cause of familial-type hepatocellular carcinoma (HCC). The route of HBV transmission differs between the children and siblings of patients with HCC. This study examined the differences in HBV carrier rates and HCC-related mortality between two generations in HCC families.
Methods
From 1992 to 1997, relatives of individuals with HCC were screened prospectively with ultrasonography, alpha-fetoprotein, liver biochemistry tests and viral markers. Total HCC-related deaths during a 9-year period were compared between the generations of index patients and their children.
Results
The study included a total of 13 676 relatives in two generations. More HCC-related deaths occurred in the index patient generation than in the child generation. Furthermore, children of female index patients had higher rates of liver cancer related mortality than children of male index patients. The same was true when the analysis was limited to male HBV carriers. The prevalence of HBsAg in the offspring of HBsAg positive mothers was 66% in the child generation and 72% in the index patient generation. These high prevalences indicated high maternal HBV replication status.
Conclusions
Perinatal transmission and maternal viral load are important risk factors in hepatocarcinogenesis.
Language eng
Field of Research 110307 Gastroenterology and Hepatology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, European Association for the Study of the Liver
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009322

Document type: Journal Article
Collection: School of Psychology
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