Survival of relatives of patients with hepatocellular carcinoma

Tai, Dar-In, Hung, Chien-Hung, Chang, Ting-Tsung, Chen, Shinn-Cherng, Liao, Li-Ying, Kuo, Chung-Huang, Chen, YangYuan, Chen, Gran-Hum, Yang, Sien-Sing, Tang, Huang-Shang, Lin, Hsien Hong, Lin, Deng-Yn, Lo, Sing Kai, Du, Jeng-Ming, Lin, Kwo-Chuan, Changchien, Chi-Sin, Chang, Wen-Yu, Sheu, Jin-Chuan, Liaw, Yun-Fan, Chen, Ding-Shinn and Sung, Juei-Low 2002, Survival of relatives of patients with hepatocellular carcinoma, Journal of gastroenterology and hepatology, vol. 17, no. 6, pp. 682-689.

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Title Survival of relatives of patients with hepatocellular carcinoma
Author(s) Tai, Dar-In
Hung, Chien-Hung
Chang, Ting-Tsung
Chen, Shinn-Cherng
Liao, Li-Ying
Kuo, Chung-Huang
Chen, YangYuan
Chen, Gran-Hum
Yang, Sien-Sing
Tang, Huang-Shang
Lin, Hsien Hong
Lin, Deng-Yn
Lo, Sing Kai
Du, Jeng-Ming
Lin, Kwo-Chuan
Changchien, Chi-Sin
Chang, Wen-Yu
Sheu, Jin-Chuan
Liaw, Yun-Fan
Chen, Ding-Shinn
Sung, Juei-Low
Journal name Journal of gastroenterology and hepatology
Volume number 17
Issue number 6
Start page 682
End page 689
Publisher Blackwell Publishing Asia
Place of publication Richmond, Vic.
Publication date 2002
ISSN 0815-9319
1440-1746
Keyword(s) familial tendency
hepatitis B
hepatitis C
hepatocellular carcinoma
Summary Background:Families of patients with hepatocellular carcinoma (HCC) carry a high risk of developing HCC. We determine the number of fatalities in relatives of HCC patients during an 8-year period to understand the risk and cause of HCC in relatives of patients with HCC.
Methods:From 1992 to 1997, 15 410 relatives of HCC patients in three generations were screened prospectively for HCC by ultrasonography, α-fetoprotein, liver biochemistry and viral markers. By using national citizen identification numbers, we searched the total fatalities in relatives of HCC patients between 1992 and 1999 from the national mortality data bank. The results were compared among different viral infection groups.
Results:Of the relatives studied, 37.8% were hepatitis B s antigen (HBsAg) positive (+), 4.3% were anti-hepatitis C virus (HCV) (+) and 1.7% were both HBsAg (+) and anti-HCV (+). A total of 399 fatalities, including 139 because of HCC (34.8%), 37 because of liver diseases (9.3%), 88 because of other cancers (22.1%) and 135 because of other diseases (33.8%), were found. Relatives who were HBsAg (+) or anti-HCV (+)showed a lower cumulative survival than did relatives who were negative for both HBsAg and anti-HCV. Relatives with dual infection of hepatitis B and C virus showed the highest mortality due to HCC or terminal liver diseases.
Conclusions:Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases.
Background:Families of patients with hepatocellular carcinoma (HCC) carry a high risk of developing HCC. We determine the number of fatalities in relatives of HCC patients during an 8-year period to understand the risk and cause of HCC in relatives of patients with HCC.
Methods:From 1992 to 1997, 15 410 relatives of HCC patients in three generations were screened prospectively for HCC by ultrasonography, α-fetoprotein, liver biochemistry and viral markers. By using national citizen identification numbers, we searched the total fatalities in relatives of HCC patients between 1992 and 1999 from the national mortality data bank. The results were compared among different viral infection groups.
Results:Of the relatives studied, 37.8% were hepatitis B s antigen (HBsAg) positive (+), 4.3% were anti-hepatitis C virus (HCV) (+) and 1.7% were both HBsAg (+) and anti-HCV (+). A total of 399 fatalities, including 139 because of HCC (34.8%), 37 because of liver diseases (9.3%), 88 because of other cancers (22.1%) and 135 because of other diseases (33.8%), were found. Relatives who were HBsAg (+) or anti-HCV (+)showed a lower cumulative survival than did relatives who were negative for both HBsAg and anti-HCV. Relatives with dual infection of hepatitis B and C virus showed the highest mortality due to HCC or terminal liver diseases.
Conclusions:Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases.
Language eng
Field of Research 110307 Gastroenterology and Hepatology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Blackwell Publishing Asia
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009323

Document type: Journal Article
Collection: School of Health Sciences
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