Interobserver reproducibility of histopathologic prognostic variables in primary cutaneous melanomas

Scolyer, Richard A., Shaw, Helen M., Thompson, John F., Colman, Marjorie H., Lo, Sing Kai, McCarthy, Stanley W., Palmer, A. Allan, Nicoll, Katherine D., Dutta, Bish, Slobedman, Eric, Watson, Geoff W. and Stretch, Jonathan R. 2003, Interobserver reproducibility of histopathologic prognostic variables in primary cutaneous melanomas, American journal of surgical pathology, vol. 27, no. 12, pp. 1571-1576, doi: 10.1097/00000478-200312000-00011.

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Title Interobserver reproducibility of histopathologic prognostic variables in primary cutaneous melanomas
Author(s) Scolyer, Richard A.
Shaw, Helen M.
Thompson, John F.
Colman, Marjorie H.
Lo, Sing Kai
McCarthy, Stanley W.
Palmer, A. Allan
Nicoll, Katherine D.
Dutta, Bish
Slobedman, Eric
Watson, Geoff W.
Stretch, Jonathan R.
Journal name American journal of surgical pathology
Volume number 27
Issue number 12
Start page 1571
End page 1576
Publisher Lippincott Willimas and Wilkins
Place of publication [Philadelphia, Pa.]
Publication date 2003-12
ISSN 0147-5185
Keyword(s) melanoma
mitotic rate
observer variation
quality control
kappa statistics
Summary Background: The prognosis for patients with localized primary cutaneous melanoma is known to depend principally on tumor thickness, and to a lesser extent on ulcerative state and Clark level. We have recently found in an analysis of 3661 patients that tumor mitotic rate (TMR) is also an important prognostic parameter, ranking second only to tumor thickness. However, few studies have assessed the accuracy and reproducibility with which these features of a melanoma are recorded by histopathologists.
Aim: To assess interobserver reproducibility of major pathologic prognostic parameters in cutaneous melanoma.
Methods: Single hematoxylin and eosin-stained slides of 69 dermally invasive primary cutaneous melanomas were circulated among six pathologists with differing experience in the assessment of melanocytic tumors. The observers independently determined the tumor thickness, Clark level of invasion, ulcerative state, and TMR for each lesion. Intraclass correlation coefficients and kappa scores for multiple ratings per subject were calculated.
Results: The intraclass correlation coefficients were 0.96 for tumor thickness and 0.76 for TMR. The kappa scores were 0.83 for ulcerative state and 0.60 for Clark level. These results indicated excellent agreement among the pathologists for measurements of tumor thickness, ulcerative state, and TMR and fair to good agreement for Clark level.
Conclusions: Appropriately trained and experienced histopathologists can assess prognostically important features of melanomas accurately and reproducibly. Given our recent finding of the significance of TMR in determining prognosis, it is important that this feature be assessed by a standardized method and documented for all primary cutaneous melanomas.
Language eng
DOI 10.1097/00000478-200312000-00011
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, Lippincott Williams & Wilkins, Inc.
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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