Modulation of tumor necrosis factor receptors 1 and 2 in chronic hepatitis B and C: The differences and implications in pathogenesis

Tai, Dar-In, Tsai, Sun-Lung, Chen, Tse-Ching, Lo, Sing Kai, Chang, Ya-Hui and Liaw, Yun-Fan 2001, Modulation of tumor necrosis factor receptors 1 and 2 in chronic hepatitis B and C: The differences and implications in pathogenesis, Journal of biomedical science, vol. 8, no. 4, pp. 321-327.

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Title Modulation of tumor necrosis factor receptors 1 and 2 in chronic hepatitis B and C: The differences and implications in pathogenesis
Author(s) Tai, Dar-In
Tsai, Sun-Lung
Chen, Tse-Ching
Lo, Sing Kai
Chang, Ya-Hui
Liaw, Yun-Fan
Journal name Journal of biomedical science
Volume number 8
Issue number 4
Start page 321
End page 327
Publisher Springer Netherlands
Place of publication Amsterdam, The Netherlands
Publication date 2001-07
ISSN 1021-7770
1423-0127
Keyword(s) hepatitis B virus
hepatitis Cvirus
histology activity index
tumor necrosis factor
tumor necrosis factor receptor
Summary Tumor necrosis factor (TNF) plays a role in the pathogenesis of chronic hepatitis B (CHB) and chronic hepatitis C (CHC). The difference in the cytokine responses between hepatitis B virus (HBV) and hepatitis C virus (HCV) infections may have implications in the pathogenesis of these diseases. We performed a comparative study to examine the possible differences in the TNF-TNF receptor (TNFR) response between CHB and CHC. We studied the cytokine levels of 38 patients with CHB, 40 patients with CHC and 9 patients with dual hepatitis B and C, and compared them with the baseline levels of 12 healthy controls. The plasma levels of TNF-, interferon-, interleukin (IL)-2, IL-4, IL-10 and soluble TNFR-1 and 2 (sTNFR-1 and 2) were quantified by enzyme-linked immunosorbent assays. The expression of TNFR-1 and 2 in liver tissues was examined in 30 cases of CHB and 15 cases of CHC by semiquantitative reverse transcription polymerase chain reaction. The results showed that sTNFR-1 levels correlated with liver inflammation in all patients, whereas this correlation was not found with sTNFR-2 or other cytokines. Liver inflammation indicators were higher in HCV RNA+ than in HCV RNA– CHC. Most significantly, sTNFR-1 levels correlated with liver inflammation in CHB, but not in CHC. However, the expression of TNFR-1 and 2 in liver was similar between CHB and CHC. These findings suggest that the TNFR signal transduction pathway is modulated differently in HBV and HCV infection.
Language eng
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, Springer; National Science Council, ROC; S. Karger AG, Basel
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009325

Document type: Journal Article
Collection: School of Health and Social Development
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