Openly accessible

Characterization of apolipoprotein E genetic variations in Taiwanese: assocation with coronary heart disease and plasma lipid levels

Wu, June, Lo, Sing Kai, Wen, Ming-Shien and Kao, Jau-Tsuen 2002, Characterization of apolipoprotein E genetic variations in Taiwanese: assocation with coronary heart disease and plasma lipid levels, Human biology, vol. 74, no. 1, pp. 25-31.

Attached Files
Name Description MIMEType Size Downloads
lo-characterization-2002.pdf Published version application/pdf 289.60KB 6

Title Characterization of apolipoprotein E genetic variations in Taiwanese: assocation with coronary heart disease and plasma lipid levels
Author(s) Wu, June
Lo, Sing Kai
Wen, Ming-Shien
Kao, Jau-Tsuen
Journal name Human biology
Volume number 74
Issue number 1
Start page 25
End page 31
Publisher Wayne State University Press
Place of publication Detroit, Mich.
Publication date 2002-02
ISSN 0018-7143
1534-6617
Keyword(s) APOE2
APOE3
APOE4
frequency distribution
genotype
Taiwanese
Summary Apolipoprotein E (apoE, protein; APOE, gene) is important in lipoprotein metabolism. Three isoforms, apoE2 (Cys112 Cys158), apoE3 (Cys112 Arg158), and apoE4 (Arg112 Arg158), are present in the general population. This report investigates the frequency distribution of apoE isoforms and the association of APOE genotypes with plasma lipid profile and coronary heart disease (CHD) in a population of Taiwan. ApoE isoforms were determined genetically by polymerase chain reaction and HhaI restriction enzyme digestion in control and coronary heart disease (CHD) patients. Plasma lipid and lipoprotein concentrations were also determined. The control group exhibited frequencies of 84.6% APOE3, 7.9% APOE4, 7.5% APOE2, 70.6% APOE3E3, 14.4% APOE3E4, 13.6% APOE2E3, and 1.4% APOE2E4. Comparable frequencies were observed in the CHD group. In both APOE2 carrier and APOE3E3 groups, the CHD patients expressed abnormal lipid profiles while the control group expressed normal lipid profiles. The APOE4 carriers, however, expressed abnormal lipid profiles in both normal control and CHD groups. Extremely high apoE levels in the hypertriglyceridemic group (TG > 400 mg/dL) seemed to be undesirable and were often observed in CHD patients
Language eng
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Wayne State University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009337

Document type: Journal Article
Collections: School of Health and Social Development
Open Access Collection
Connect to link resolver
 
Link to Related Work
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 15 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 378 Abstract Views, 6 File Downloads  -  Detailed Statistics
Created: Mon, 13 Oct 2008, 15:57:58 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.