Environmental risk factors of young onset Parkinson`s disease: a case-control study

Tsai, C., Lo, Sing Kai, See, L., Chen, H., Chen, R., Weng, Y., Chang, F. and Lu, C. 2002, Environmental risk factors of young onset Parkinson`s disease: a case-control study, Clinical neurology and neurosurgery, vol. 104, no. 4, pp. 328-333, doi: 10.1016/S0303-8467(02)00027-6.

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Title Environmental risk factors of young onset Parkinson`s disease: a case-control study
Author(s) Tsai, C.
Lo, Sing Kai
See, L.
Chen, H.
Chen, R.
Weng, Y.
Chang, F.
Lu, C.
Journal name Clinical neurology and neurosurgery
Volume number 104
Issue number 4
Start page 328
End page 333
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2002-09
ISSN 0303-8467
Keyword(s) environment
Parkinson's disease
risk factor
Summary While the cause of Parkinson's disease (PD) remains unknown, recent evidence suggests certain environmental factors, such as well water drinking, herbicides and pesticides exposure, and neurotoxins, may trigger the chain of oxidative reactions culminating in the death of dopaminergic neurons in substantia nigra to cause parkinsonism. Most studies to date focused on PD with old age onset. However, there is a peculiar group of parkinsonian patients, the young onset Parkinson's disease (YOPD), in whom the age of onset is before 40. It is intriguing to know whether earlier exposure to the putative neurotoxin(s) may contribute to the earlier onset. We therefore conducted this case-control study in which 60 PD patients, 30 YOPD patients and the same number of age- and sex-matched young controls were included. Using logistic regression, we found well water drinking and head injury were risk factors for the development of YOPD. When YOPD patients were compared with PD, we found head injury and exercise were the significant predictors. Keeping all other variables constant, head injury was a risk factor and exercise appeared to be a protective factor. We conclude early exposure to well water drinking and head trauma may trigger and expedite the appearance of parkinsonian features, but such acceleration may be prevented through regular exercise.
Language eng
DOI 10.1016/S0303-8467(02)00027-6
Field of Research 110399 Clinical Sciences not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Elsevier Science B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009345

Document type: Journal Article
Collections: Faculty of Health
School of Health Sciences
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