The current pattern of hepatitis B virus infectiion in Australia

Tawk, H., Vickery, K., Bisset, l., Lo, Sing Kai, Selby, W. and Cossart, Y. 2006, The current pattern of hepatitis B virus infectiion in Australia, Journal of viral hepatitis, vol. 13, no. 3, pp. 206-215.

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Title The current pattern of hepatitis B virus infectiion in Australia
Author(s) Tawk, H.
Vickery, K.
Bisset, l.
Lo, Sing Kai
Selby, W.
Cossart, Y.
Journal name Journal of viral hepatitis
Volume number 13
Issue number 3
Start page 206
End page 215
Publisher Blackwell Publishing Ltd.
Place of publication Abingdon, England
Publication date 2006-09
ISSN 1352-0504
1365-2893
Keyword(s) Australia
endoscopy
hepatitis B infection
prevalence
risk factors
Summary Summary. There is little recent data of the seroprevalence of hepatitis B in Australia. We have surveyed a large cohort of endoscopy patients attending a teaching hospital in central Sydney, and related the presence of hepatitis B virus (HBV) markers with putative risk factors for exposure using the SAS statistical package. Of the 2115 patients tested: 2.1% (45/2115) were HBV surface antigen positive, 0.75% (14/2115) viraemic, 9.5% (200/2115) anti-HBs and anti-HBc positive, 20.1% (430/2115) vaccinated (anti-HBs only) and the remaining 70% were susceptible. The adjusted OR of HBV infection was significantly increased in patients who had been diagnosed with human immunodeficiency virus (36.3-fold), born in Asia or Pacific islands (12.4-fold), born in North Africa, Middle East & Mediterranean countries (6-fold) or born abroad elsewhere in the world (2.7-fold), had household contact with someone diagnosed with hepatitis between 1980 and 1990 (3.9-fold), injected drugs between 1980 and 1990 (4.4-fold), resided in a military establishment for 3 months (2.3-fold) or in a hospital for 3 months (2.2-fold), never been vaccinated for hepatitis B (2.8-fold), received blood transfusion due to an accident and/or a haemorrhage (1.92-fold) and finally been a male gender (1.59-fold). The prevalence of HBV in this hospital population was higher than predicted on the basis of notifications to the passive surveillance scheme. Most HBV patients had multiple risk factors for infection, but the hierarchy of odds ratios provides a rational basis for targeted programmes to identify asymptomatic HBV carriers who might benefit from treatment.
Language eng
Field of Research 110307 Gastroenterology and Hepatology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Blackwell Publishing Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009351

Document type: Journal Article
Collection: School of Health and Social Development
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