Replication of hepatitis B in HBsAg-positive siblings

Tai, Dar-In, Lo, Sing Kai, Kuo, Chung-Huang, Du, Jeng-Ming, Chen, Chien-Hung, Hung, Ching-Shu and Chu, Chia-Ming 2002, Replication of hepatitis B in HBsAg-positive siblings, Journal of viral hepatitis, vol. 9, no. 4, pp. 272-279.

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Title Replication of hepatitis B in HBsAg-positive siblings
Author(s) Tai, Dar-In
Lo, Sing Kai
Kuo, Chung-Huang
Du, Jeng-Ming
Chen, Chien-Hung
Hung, Ching-Shu
Chu, Chia-Ming
Journal name Journal of viral hepatitis
Volume number 9
Issue number 4
Start page 272
End page 279
Publisher Blackwell Publishing Ltd.
Place of publication Abingdon, England
Publication date 2002-06
ISSN 1352-0504
1365-2893
Keyword(s) familial tendency
hepatitis B virus
hepatocellular carcinoma
maternal–fetal exchange
sibling order
Summary Persistent hepatitis B virus (HBV) replication is important for progression of chronic liver diseases. To understand whether there is a trend of HBV replication in siblings or not, 1850 relatives of patients with hepatocellular carcinoma (HCC) were examined prospectively for liver function test, viral markers and HBV DNA. The prevalence of HBsAg in the parents', siblings', children's and grandchildren's generations were 43.4%, 57.2%, 35.5% and 32.1%, respectively. The prevalence of hepatitis B e antigen (HBeAg) in sibling's generation (mean age 44.4 years) was 19%, which is higher than that of asymptomatic HBsAg carriers. For siblings in the children's generation, the prevalence of HBeAg in hepatitis B surface antigen (HBsAg) carriers declined from 40% in the eldest siblings to 19% in the youngest siblings. In 75 families clustered with three or more HBsAg carrier siblings, the mean age for seven families of which all siblings remained HBeAg + was younger, whereas the mean age for 35 families of which all siblings had cleared HBeAg was older. For the remaining 33 families, in only 10 families had the older siblings cleared the HBeAg earlier than the younger siblings. Twenty families showed that younger siblings cleared the HBeAg earlier than the older or middle siblings. We concluded that HBV replication in HCC relatives cannot be explained by familial tendency alone. A significant number of younger siblings appeared to have a shorter HBV replication phase than their older siblings. The possible role of this in maternal–fetal transmission is discussed.
Language eng
Field of Research 110399 Clinical Sciences not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Blackwell Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009361

Document type: Journal Article
Collection: School of Health Sciences
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