Plasma coagulation factor VII activity and its corrlates in healthy men

Li, D., Turner, A. and Sinclair, Andrew 2005, Plasma coagulation factor VII activity and its corrlates in healthy men, European journal of clinical nutrition, vol. 59, no. 12, pp. 1423-1428, doi: 10.1038/sj.ejcn.1602257.

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Title Plasma coagulation factor VII activity and its corrlates in healthy men
Author(s) Li, D.
Turner, A.
Sinclair, Andrew
Journal name European journal of clinical nutrition
Volume number 59
Issue number 12
Start page 1423
End page 1428
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2005
ISSN 0954-3007
Keyword(s) haemostatic factor VII activity
plasma PL fatty acids
stearic acid
Summary Objective: The aim of this study was to investigate the plasma coagulation factor VII activity and its correlates in healthy Australian men.
Design: Cross-sectional study.
Setting: Free living subjects.
Subjects: A total of 139 healthy Australian males aged 20–55 y with widely varying intakes of individual fatty acids.
Outcome measures: The concentration of phospholipid fatty acids and the parameters of biochemistry were analysed by standard methods. Citrated plasma factor VII activity was measured by using the ACL 200 system with commercially available kits.
Results: In the stepwise multiple regression, controlled for age, body mass index and dietary groups, the two most important variables of factor VII activity were selected in the forward entry model with R2¼0.474 and Po0.0001 from 19 independent variables, which were significantly correlated with plasma factor VII activity in age-adjusted bivariate analysis where significance was considered at Po0.01. Plasma factor VII activity was strongly negatively correlated with prothrombin time (PT) (Std. Coeff. -0.550), and significantly positively correlated with plasma phospholipid (PL) stearic acid (Std. Coeff. 0.285).
Conclusions: Increased factor VII activity was associated with shortening of PT. All types of fatty-acid concentrations of PLs were
significantly positively correlated with factor VII activity; however, stearic acid was more potent than other fatty acids in healthy Australian men.
Sponsorship: Meat Research Corporation of Australia.
Language eng
DOI 10.1038/sj.ejcn.1602257
Field of Research 060101 Analytical Biochemistry
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Nature Publishing Group
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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