Increased blood pressure later in life may be associated with perinatal n-3 fatty acid deficiency

Armitage, James A., Pearce, Adrian D., Sinclair, Andrew, Vingrys, Algis J., Weisinger, Richard S. and Weisinger, Harrison S. 2003, Increased blood pressure later in life may be associated with perinatal n-3 fatty acid deficiency, Lipids, vol. 38, no. 4, pp. 459-464.

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Title Increased blood pressure later in life may be associated with perinatal n-3 fatty acid deficiency
Author(s) Armitage, James A.
Pearce, Adrian D.
Sinclair, Andrew
Vingrys, Algis J.
Weisinger, Richard S.
Weisinger, Harrison S.
Journal name Lipids
Volume number 38
Issue number 4
Start page 459
End page 464
Publisher Springer Berlin
Place of publication Berlin, Germany
Publication date 2003-04
ISSN 0024-4201
1558-9307
Summary Hypertension is a major risk factor for cardiovascular and cerebrovascular disease. Previous work in both animals and humans with high blood pressure has demonstrated the antihypertensive effects of n−3 polyunsaturated fatty acids (PUFA), although it is not known whether these nutrients are effective in preventing hypertension. The predominant n−3 PUFA in the mammalian nervous system, docosahexaenoic acid (DHA), is deposited into synaptic membranes at a high rate during the perinatal period, and recent observations indicate that the perinatal environment is important for the normal development of blood pressure control. This study investigated the importance of perinatal n−3 PUFA supply in the control of blood pressure in adult Sprague-Dawley rats. Pregnant rat dams were fed semisynthetic diets that were either deficient in (DEF) or supplemented with (CON) n−3 PUFA. Offspring were fed the same diets as their mothers until 9 wk; then, half of the rats from each group were crossed over to the opposite diet, creating four groups, i.e., CON-CON; CON-DEF; DEF-DEF, DEF-CON. Mean arterial blood pressures (MAP) were measured directly, at 33 wk of age, by cannulation of the femoral artery. The phospholipid fatty acid profile of the hypothalamic region was determined by capillary gas-liquid chromatography. The tissue phospholipid fatty acid profile reflected the diet that the rats were consuming at the time of testing. Both groups receiving DEF after 9 wk of age (i.e., DEF-DEF and CON-DEF) had similar profiles with a reduction in DHA levels of 30%, compared with rats receiving CON (i.e., CON-CON and DEF-CON). DEF-DEF rats had significantly raised MAP compared with all other groups, with differences as great as 17 mm Hg. DEF-CON rats had raised MAP compared with CON-CON rats, and DEF-DEF rats had higher MAP than CON-DEF rats, despite the fact that their respective fatty acid profiles were not different. These findings indicate that inadequate levels of DHA in the perinatal period are associated with altered blood pressure control in later life. The way in which these long-term effects are produced remains to be elucidated.

Notes SpringerLink Date Thursday, December 07, 2006
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009379

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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