Does perinatal ω-3 polyunsaturated fatty acid deficiency increase appetite signaling?

Mathai, Michael L., Soueid, Mona, Chen, Nora, Jayasooriya, Anura P., Sinclair, Andrew, Wlodek, Mary E., Weisinger, Harrison S. and Weisinger, Richard S. 2004, Does perinatal ω-3 polyunsaturated fatty acid deficiency increase appetite signaling?, Obesity, vol. 12, no. 11, pp. 1886-1894.

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Title Does perinatal ω-3 polyunsaturated fatty acid deficiency increase appetite signaling?
Author(s) Mathai, Michael L.
Soueid, Mona
Chen, Nora
Jayasooriya, Anura P.
Sinclair, Andrew
Wlodek, Mary E.
Weisinger, Harrison S.
Weisinger, Richard S.
Journal name Obesity
Volume number 12
Issue number 11
Start page 1886
End page 1894
Publisher North American Association for the Study of Obesity
Place of publication Silver Spring, Md.
Publication date 2004-11
ISSN 1930-7381
1930-739X
Keyword(s) 2-deoxyglucose
beta-mercaptoacetate
hyperphagia
perinatal programming
omega-3 polyunsaturated fatty acids
Summary Objective: To investigate the effect of maternal dietary ω-3 polyunsaturated fatty acid (PUFA) deficiency and repletion on food appetite signaling.
Research Methods and Procedures: Sprague-Dawley rat dams were maintained on diets either supplemented with (CON) or deficient in (DEF) ω-3 PUFA. All offspring were raised on the maternal diet until weaning. After weaning, two groups remained on the respective maternal diet (CON and DEF groups), whereas a third group, born of dams fed the DEF diet, were switched to the CON diet (REC). Experiments on food intake began when the male rats reached 16 weeks of age. Food intake was stimulated either by a period of food restriction, by blocking glucose utilization (by 2-deoxyglucose injection), or by blocking β-oxidation of fatty acids (by β-mercaptoacetate injection).
Results: DEF animals consumed more than CON animals in response to all stimuli, with the greatest difference (1.9-fold) demonstrated following administration of 2-deoxyglucose. REC animals also consumed more than CON animals in response to food restriction and 2-deoxyglucose but not to β-mercaptoacetate.
Discussion: These findings indicate that supply of ω-3 PUFA, particularly during the perinatal period, plays a role in the normal development of mechanisms controlling food intake, especially glucoprivic (i.e. reduced glucose availability) appetite signaling. Dietary repletion of ω-3 PUFA from 3 weeks of age restored intake responses to fatty acid metabolite signaling but did not reverse those in response to food restriction or glucoprivic stimuli.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, North American Association for the Study of Obesity
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009386

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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