The effect of exercise and training status on platelet activation: do cocoa polyphenols play a role?

Singh, Indu, Quinn, H., Mok, M., Southgate, R., Turner, A., Li, D., Sinclair, Andrew and Hawley, John 2006, The effect of exercise and training status on platelet activation: do cocoa polyphenols play a role?, Platelets, vol. 17, no. 6, pp. 361-367.

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Title The effect of exercise and training status on platelet activation: do cocoa polyphenols play a role?
Author(s) Singh, Indu
Quinn, H.
Mok, M.
Southgate, R.
Turner, A.
Li, D.
Sinclair, Andrew
Hawley, John
Journal name Platelets
Volume number 17
Issue number 6
Start page 361
End page 367
Publisher Churchill Livingstone
Place of publication Edinburgh, Scotland
Publication date 2006-09
ISSN 0953-7104
1369-1635
Keyword(s) cardiovascular disease
cocoa powder antioxidant
platelet aggregation
platelet activation
exercise
training
Summary Sedentary and trained men respond differently to the same intensity of exercise, this is probably related to their platelet reactivity and antioxidant capacity. There is growing interest in the utilization of antioxidant-rich plant extracts as dietary food supplements. The aim of this study was to investigate the effect of an acute bout of sub maximal exercise on platelet count and differential response of platelet activation in trained and sedentary subjects and to observe if cocoa polyphenols reverse the effect of exercise on platelet function. The practical significance of this study was that many sedentary people engage in occasional strenuous exercise that may predispose them to risk of heart disease. Fasting blood samples were collected from 16 male subjects, pre and post 1-h cycling exercise at 70% of maximal aerobic power (VO2max) before and after consumption of cocoa or placebo. Agonist stimulated citrated whole blood was utilized for measuring platelet aggregation, adenosine triphosphate (ATP) release and platelet activation. Baseline platelet count (221 ± 33 times 109/L) and ATP release (1.4 ± 0.6 nmol) increased significantly (P < 0.05) after exercise in all subjects. Baseline platelet numbers in the trained were higher (P < 0.05) than in the sedentary (235 ± 37 vs. 208 ± 34 times 109/L), where as platelet activation in trained was lower (P < 0.05) than sedentary (51 ± 6 vs. 59 ± 5%). Seven days of cocoa polyphenol supplementation had little effect on any of the parameters measured. We conclude that trained subjects show decreased activation of stimulated platelets when compared to the sedentary subjects and short-term cocoa polyphenol supplementation did not decrease platelet activity in response to exercise independent of prior training status.
Language eng
Field of Research 069999 Biological Sciences not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Informa UK Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009411

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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