This book for the first time comprehensively surveys the research investigating the Jak-Stat pathway and its role in normal blood development as well as its perturbation in disease. It draws on the expertise of world-renowned medical researchers to take the reader from basic biology through to recent therapeutic advances.
Contents: Jaks and normal hematopoiesis -- Jak3-dependent pathways in hematopoiesis and SCID -- Stat activation by Src, Fes and Btk tyrosine kinases -- Stats and hematopoiesis --Stat signaling in leukemia: implications for pathogenesis and treatment -- The role of the Jak-Stat pathway in hematopoiesis and immune responses in Drosophila -- SOCS proteins in hematopoiesis.
Field of Research
060111 Signal Transduction
Socio Economic Objective
970106 Expanding Knowledge in the Biological Sciences
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