Profile of dyslipodemia in psammomys obesus, an animal model of the metabolic syndrome

Walder, Ken, Oakes, Nick, Fahey, Richard, Cooney, Gregory, Zimmet, Paul and Collier, Gregory 2002, Profile of dyslipodemia in psammomys obesus, an animal model of the metabolic syndrome, Endocrine regulations, vol. 36, no. 1, pp. 1-8.


Title Profile of dyslipodemia in psammomys obesus, an animal model of the metabolic syndrome
Author(s) Walder, Ken
Oakes, Nick
Fahey, Richard
Cooney, Gregory
Zimmet, Paul
Collier, Gregory
Journal name Endocrine regulations
Volume number 36
Issue number 1
Start page 1
End page 8
Publisher Slovak Academic Press Ltd
Place of publication Bratislava, Czech and Slovak Federal Republic
Publication date 2002
ISSN 1210-0668
Keyword(s) dyslipidemia
psammomys obesus
metabolic syndrome
Summary Objective. To investigate lipid profiles in Psammomys obesus and relationships between lipid profile and other components of the Metabolic Syndrome.

Methods.
A total number of 49 adults with a wide range of body weight and glucose tolerance were studied in a cross-sectional analysis. Plasma cholesterol distribution profiles were measured by size exclusion lipid chromatography. Blood glucose was measured using an enzymatic glucose analyser, and plasma insulin was determined by radioimmunossay.

Results.
Obese diabetic Psammomys obesus had elevated plasma cholesterol (P=0.003) and triglyceride levels (p>0.001) compared to their lean littermates. The hypercholesterolemia was mainly due to increased circulating levels of VLDL-cholesterol (P=0.003) and LDL-cholesterol (P=0.003) in these animals. Multiple linear regression analyses revealed that body weight was independently associated with plasma cholesterol (P=0.011) and LDL concentration (P=0.009), while plasma insulin was associated with VLDL-cholesterol concentration (P=0.005). All of the variables measured exhibited continuous distributions across a wide range of phenotypes, from a normal rodent lipid profile to profound dyslipidemia.

Conclusions.
These data suggest that the dyslipidemia in obese, diabetic Psammomys obesus is closely associated with other components of the Metabolic Syndrome, including obesity and insulin resistance.
Language eng
Field of Research 060602 Animal Physiology - Cell
HERDC Research category C3 Non-refereed articles in a professional journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30012632

Document type: Journal Article
Collection: School of Health Sciences
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