Markers of inflammation in South Asian and European infants from birth to 2 years in Manchester, UK

Oldroyd, J., Heald, A., Gibson, M., Vyas, A., McElduff, P., Clayton, P. and Cruickshank, K. 2005, Markers of inflammation in South Asian and European infants from birth to 2 years in Manchester, UK, in AEA 2005 : Australasian Epidemiological Association Conference. Proceedings, Australasian Epidemiological Association, [Newcastle, N.S.W.].

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Title Markers of inflammation in South Asian and European infants from birth to 2 years in Manchester, UK
Author(s) Oldroyd, J.
Heald, A.
Gibson, M.
Vyas, A.
McElduff, P.
Clayton, P.
Cruickshank, K.
Conference name Australasian Epidemiological Association Conference (2005 : Newcastle, N.S.W.)
Conference location Newcastle, N.S.W.
Conference dates 5-7 Oct. 2005
Title of proceedings AEA 2005 : Australasian Epidemiological Association Conference. Proceedings
Publication date 2005
Publisher Australasian Epidemiological Association
Place of publication [Newcastle, N.S.W.]
Summary Inflammatory markers, including serum C-reactive protein (CRP), are predictors of coronary heart disease (CHD) in adults. South Asians in the UK have higher rates of CHD in adulthood than national rates.We tested the hypotheses that South Asian infants would have higher serum concentrations of CRP and homocysteine than European infants up to 2 years of age and that higher infant weight is associated with elevation of inflammatory markers. Infants of South Asian and European origin were investigated in a mixed cross sectional-longitudinal cohort study. Mothers were recruited ante-natally from St Mary’s Hospital,Manchester by postal invitation and telephone call to non-responders. Infants with metabolic or congenital abnormalities, known syndromes or pre-maturity were excluded. Measurements were collected at birth and either 3, 6, 12 or 24 months. High sensitivity CRP and homocysteine were measured by an immulite immunoassay. We used mixed linear modelling to assess whether infant weight, ethnicity, length of follow-up or their interaction were associated with inflammatory makers in infants during follow-up. Data are presented on 306 infants (109 South Asian and 197 European). We found that European infants had higher serum CRP than South Asian infants during follow-up which was of borderline significance.There was no difference in serum homocysteine between ethnic groups during followup and no significant interaction between ethnicity and follow-up. Infant weight was significantly associated with CRP but not homocysteine. In this ongoing longitudinal study,we found little difference in inflammatory markers in infants from birth to 2 years despite markedly higher rates of CHD in South Asian than European adults. Life course exposure to risk factors may play a more dominant role in the development of CHD.
Notes Poster Presentation. Abstract published in Australasian Epidemiologist, Vol. 12, No. 3, Oct 2005: 55-65.
ISSN 1327-8835
Language eng
Field of Research 111706 Epidemiology
Socio Economic Objective 920599 Specific Population Health (excl. Indigenous Health) not elsewhere classified
HERDC Research category E3 Extract of paper
Copyright notice ©2005, Australasian Epidemiological Association
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