A screening test for heroin based on sequential injection analysis with dual-reagent chemiluminescence detection

Hill, Lauren A., Lenehan, Claire E., Francis, Paul S., Adcock, Jacqui L., Gange, Michelle E., Pfeffer, Frederick M. and Barnett, Neil W. 2008, A screening test for heroin based on sequential injection analysis with dual-reagent chemiluminescence detection, Talanta, vol. 76, no. 3, pp. 674-679.

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Title A screening test for heroin based on sequential injection analysis with dual-reagent chemiluminescence detection
Author(s) Hill, Lauren A.
Lenehan, Claire E.
Francis, Paul S.
Adcock, Jacqui L.
Gange, Michelle E.
Pfeffer, Frederick M.
Barnett, Neil W.
Journal name Talanta
Volume number 76
Issue number 3
Start page 674
End page 679
Total pages 6
Publisher Elsevier B.V.
Place of publication Amsterdam, The Netherlands
Publication date 2008-07-30
ISSN 0039-9140
1873-3573
Keyword(s) sequential injection analysis
sandwich technique
chemiluminescence detection
acidic potassium permanganate
tris(2,2′-bipyridine)ruthenium(III)
opiate alkaloids
heroin
morphine
Summary A sequential injection analysis procedure with dual-reagent chemiluminescence detection was applied to the screening of street drug seizure samples for the presence of heroin. The chemiluminescence reagents (acidic potassium permanganate and tris(2,2′-bipyridine)ruthenium(III)) were aspirated from either side of a sample aliquot that was sufficiently large to prevent interdispersion of the reagent zones, and therefore two different chemical reactions could be performed simultaneously at either end of the sample zone. The presence of heroin in seizure samples was indicated by a strong response with the tris(2,2′-bipyridine)ruthenium(III) reagent and confirmed by a significant increase in the response with the permanganate reagent when the sample was treated with sodium hydroxide to hydrolyse the heroin to morphine. Nicomorphine (a morphine-derived pharmaceutical) was synthesised and tested under the same conditions. The responses with the permanganate reagent were similar to those for heroin, which supports the proposed chemical basis for the test. However, the responses with tris(2,2′-bipyridine)ruthenium(III) were far lower for nicomorphine than heroin (approximately 5-fold for the samples that had not been hydrolysed).
Language eng
Field of Research 030103 Flow Analysis
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2008
Copyright notice ©2008, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30017271

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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