Preventing the onset of depressive disorders : a meta-analytic review of psychological interventions

Cuijpers, Pim, van Straten, Annemieke, Smit, Filip, Mihalopoulos, Cathrine and Beekman, Aartjan 2008, Preventing the onset of depressive disorders : a meta-analytic review of psychological interventions, American journal of psychiatry, vol. 165, pp. 1272-1280.


Title Preventing the onset of depressive disorders : a meta-analytic review of psychological interventions
Author(s) Cuijpers, Pim
van Straten, Annemieke
Smit, Filip
Mihalopoulos, Cathrine
Beekman, Aartjan
Journal name American journal of psychiatry
Volume number 165
Start page 1272
End page 1280
Publisher American Psychiatric Publishing
Place of publication Baltimore, Md.
Publication date 2008
ISSN 0002-953X
1535-7228
1139-3475
Summary OBJECTIVE: A growing number of studies have tested the efficacy of preventive interventions in reducing the incidence of depressive disorders. Until now, no meta-analysis has integrated the results of these studies. METHOD: The authors conducted a meta-analysis. After a comprehensive literature search, 19 studies were identified that met inclusion criteria. The studies had to be randomized controlled studies in which the incidence of depressive disorders (based on diagnostic criteria) in an experimental group could be compared with that of a control group. RESULTS: The mean incidence rate ratio was 0.78, indicating a reduction of the incidence of depressive disorders by 22% in experimental compared with control groups. Heterogeneity was low to moderate (I2=33%). The number needed to treat to prevent one case of depressive disorder was 22. Moderator analyses revealed no systematic differences between target populations or types of prevention (universal, selective, or indicated). The data included indications that prevention based on interpersonal psychotherapy may be more effective than prevention based on cognitive-behavioral therapy. CONCLUSIONS: Prevention of new cases of depressive disorders does seem to be possible. Prevention may become an important way, in addition to treatment, to reduce the enormous public health burden of depression in the coming years.
Language eng
Field of Research 111716 Preventive Medicine
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2008
Copyright notice ©2008 American Psychiatric Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30017369

Document type: Journal Article
Collection: Public Health Research, Evaluation, and Policy Cluster
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