Maternal creatine : does it reach the fetus and improve survival after an acute hypoxic episode in the spiny mouse (Acomys cahirinus)?

Ireland, Zoe, Dickinson, Hayley, Snow, Rod and Walker, David W. 2008, Maternal creatine : does it reach the fetus and improve survival after an acute hypoxic episode in the spiny mouse (Acomys cahirinus)?, American journal of obstetrics and gynecology, vol. 198, no. 4, pp. 431.e1-431.e6.

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Title Maternal creatine : does it reach the fetus and improve survival after an acute hypoxic episode in the spiny mouse (Acomys cahirinus)?
Author(s) Ireland, Zoe
Dickinson, Hayley
Snow, Rod
Walker, David W.
Journal name American journal of obstetrics and gynecology
Volume number 198
Issue number 4
Start page 431.e1
End page 431.e6
Publisher Mosby, Inc
Place of publication Ann Arbor, Mich.
Publication date 2008-04
ISSN 0002-9378
1097-6868
Keyword(s) creatine
hypoxia
neonatal survival
spiny mouse
Summary Objective
We hypothesized that elevating creatine in the maternal diet would reach fetal and placental tissues and improve fetal survival after acute hypoxia at birth.
Study Design
Pregnant spiny mice were fed a control or 5% creatine-supplemented diet from day 20 of gestation (term, approximately 39 days). On days 37-38, intrauterine hypoxia was induced by placement of the isolated uterus in a saline solution bath for 7.5-8 minutes, after which fetuses were expelled from the uterus and resuscitation was attempted by manual palpation of the chest. Total creatine content (creatine + phosphocreatine) of placental, fetal, and maternal organs was measured.
Results
The maternal creatine diet significantly increased total creatine content in the placenta, fetal brain, heart, liver, and kidney and increased the capacity of offspring to survive birth hypoxia. Maternal creatine improved postnatal growth after birth hypoxia.
Conclusion
This study provides evidence that creatine has potential as a prophylactic therapy for pregnancies that are classified as high risk for fetal hypoxia.
Language eng
Field of Research 111401 Foetal Development and Medicine
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2008
Copyright notice ©2008, Mosby, Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30017387

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