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Exercise-induced activation of STAT3 signaling is increased with age

Trenerry, Marissa, Carey, Kate, Ward, Alister, Farnfield, Michelle M. and Cameron-Smith, David 2008, Exercise-induced activation of STAT3 signaling is increased with age, Rejuvenation research, vol. 11, no. 4, pp. 717-724.

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Title Exercise-induced activation of STAT3 signaling is increased with age
Author(s) Trenerry, Marissa
Carey, Kate
Ward, Alister
Farnfield, Michelle M.
Cameron-Smith, David
Journal name Rejuvenation research
Volume number 11
Issue number 4
Start page 717
End page 724
Total pages 8
Publisher Mary Ann Liebert Publishers
Place of publication New Rochelle, N.Y.
Publication date 2008-08
ISSN 1549-1684
1557-8577
Summary Activation of the transcription factor signal transducers and activators of transcription (STAT) 3 is common to many inflammatory cytokines and growth factors, with recent evidence of involvement in skeletal muscle regeneration. The purpose of this study was to determine whether STAT3 signaling activation is regulated differentially, at rest and following intense resistance exercise, in aged human skeletal muscle. Skeletal muscle biopsies were harvested from healthy younger (n = 11, 20.4 ± 0.8 years) and older men (n = 10, 67.4 ± 1.3 years) under resting conditions and 2 h after the completion of resistance exercise. No differences were evident at rest, whereas the phosphorylation of STAT3 was significantly increased in old (23-fold) compared to young (5-fold) subjects after exercise. This correlated with significantly higher induction of the STAT3 target genes including; interleukin-6 (IL-6), JUNB, c-MYC, and suppressor of cytokine signaling (SOCS) 3 mRNA in older subjects following exercise. Despite increased SOCS3 mRNA, cellular protein abundance was suppressed. SOCS3 protein is an important negative regulator of STAT3 activation and cytokine signaling. Thus, in aged human muscle, elevated responsiveness of the STAT3 signaling pathway and suppressed SOCS3 protein are evident following resistance exercise. These data suggest that enhanced STAT3 signaling responsiveness to proinflammatory factors may impact on mechanisms of muscle repair and regeneration.
Language eng
Field of Research 110308 Geriatrics and Gerontology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2008
Copyright notice ©2008, Mary Ann Liebert Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30017521

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.