Stat5 as a diagnostic marker for leukemia

Lewis, Rowena S. and Ward, Alister 2008, Stat5 as a diagnostic marker for leukemia, Expert review of molecular diagnostics, vol. 8, no. 1, pp. 73-82.

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Title Stat5 as a diagnostic marker for leukemia
Author(s) Lewis, Rowena S.
Ward, Alister
Journal name Expert review of molecular diagnostics
Volume number 8
Issue number 1
Start page 73
End page 82
Total pages 10
Publisher Expert Reviews Ltd
Place of publication London, England
Publication date 2008-01
ISSN 1473-7159
Keyword(s) Molecular diagnosis
Summary The Jak-Stat-Socs pathway is an important component of cytokine receptor signaling. Not surprisingly, perturbation of this pathway is implicated in diseases of hematopoietic and immune origin, including leukemia, lymphoma and immune deficiencies. This review examines the role of a key component of this pathway, Stat5. This has been shown to be activated in a variety of leukemias and myeloproliferative disorders, including downstream of a range of key oncogenes where it has been shown to play an important role in mediating their effects. Therefore, Stat5 represents a useful pan-leukemia/myeloproliferative disorder diagnostic marker and key therapeutic end point, as well as representing an attractive therapeutic target for these disorders.
Language eng
Field of Research 110202 Haematology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2008
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Document type: Journal Article
Collections: School of Medicine
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