Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance

Jayasooriya, Anura P., Mathai, Michael L., Walker, Lesley L., Begg, Denovan P., Denton, Derek A., Cameron-Smith, David, Egan, Gary F., McKinley, Michael J., Rodger, Paula D., Sinclair, Andrew, Wark, John D., Weisinger, Harrison S., Jois, Mark and Weisinger, Richard S. 2008, Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance, Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 18, pp. 6531-6536.

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Title Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance
Author(s) Jayasooriya, Anura P.
Mathai, Michael L.
Walker, Lesley L.
Begg, Denovan P.
Denton, Derek A.
Cameron-Smith, David
Egan, Gary F.
McKinley, Michael J.
Rodger, Paula D.
Sinclair, Andrew
Wark, John D.
Weisinger, Harrison S.
Jois, Mark
Weisinger, Richard S.
Journal name Proceedings of the National Academy of Sciences of the United States of America
Volume number 105
Issue number 18
Start page 6531
End page 6536
Total pages 6
Publisher National Academy of Sciences
Place of publication Washington, D.C.
Publication date 2008-05
ISSN 0027-8424
1091-6490
Keyword(s) fatty acid metabolism
obesity
ACE knockout mice
glucose tolerance
Summary In addition to its role in the storage of fat, adipose tissue acts as an endocrine organ, and it contains a functional renin-angiotensin system (RAS). Angiotensin-converting enzyme (ACE) plays a key role in the RAS by converting angiotensin I to the bioactive peptide angiotensin II (Ang II). In the present study, the effect of targeting the RAS in body energy homeostasis and glucose tolerance was determined in homozygous mice in which the gene for ACE had been deleted (ACE-/-) and compared with wild-type littermates. Compared with wild-type littermates, ACE-/- mice had lower body weight and a lower proportion of body fat, especially in the abdomen. ACE-/- mice had greater fed-state total energy expenditure (TEE) and resting energy expenditure (REE) than wild-type littermates. There were pronounced increases in gene expression of enzymes related to lipolysis and fatty acid oxidation (lipoprotein lipase, carnitine palmitoyl transferase, long-chain acetyl CoA dehydrogenase) in the liver of ACE-/- mice and also lower plasma leptin. In contrast, no differences were detected in daily food intake, activity, fed-state plasma lipids, or proportion of fat excrete in fecal matter. In conclusion, the reduction in ACE activity is associated with a decreased accumulation of body fat, especially in abdominal fat depots. The decreased body fat in ACE-/- mice is independent of food intake and appears to be due to a high energy expenditure related to increased metabolism of fatty acids in the liver, with the additional effect of increased glucose tolerance.
Language eng
Field of Research 110107 Metabolic Medicine
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2008
Copyright notice ©2008, The National Academy of Sciences of the USA
Persistent URL http://hdl.handle.net/10536/DRO/DU:30017663

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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