Protein kinase C isozymes as potential therapeutic targets in immune disorders

Lee, Matthew, Duan, Wei and Tan, Seng-Lai 2008, Protein kinase C isozymes as potential therapeutic targets in immune disorders, Expert opinion on therapeutic targets, vol. 12, no. 5, pp. 535-552, doi: 10.1517/14728222.12.5.535.

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Title Protein kinase C isozymes as potential therapeutic targets in immune disorders
Author(s) Lee, Matthew
Duan, WeiORCID iD for Duan, Wei
Tan, Seng-Lai
Journal name Expert opinion on therapeutic targets
Volume number 12
Issue number 5
Start page 535
End page 552
Total pages 18
Publisher Informa Healthcare
Place of publication London, England
Publication date 2008-05
ISSN 1472-8222
Keyword(s) asthma
inflammatory bowel disease (IBD)
kinase inhibitor
protein kinase C (PKC)
rheumatoid arthritis (RA)
systemic lupus erythematosus (SLE)
Summary Background: Members of the protein kinase C (PKC) family are key signalling mediators in immune responses, and pharmacological inhibition of PKCs may be useful for treating immune-mediated diseases. Objective: To review and discuss the insights gained so far into various PKC isozymes and the therapeutic potential and challenges of developing PKC inhibitors for immune disorder therapy. Methods: A literature review of the role of PKCs in immune cell signalling and recent studies describing immune functions associated with PKC isozyme deficiency in relevant mouse disease models, followed by specific case studies of current and potential therapeutic strategies targeting PKCs. Results/conclusion: There is vast amount of data supporting PKC isozymes as attractive drug targets for certain immune disorders. Although the development of specific PKC isozyme inhibitors has been challenging, some progress has been made. It remains to be seen if broad-scale or isozyme-selective inhibition of PKC will have clinical efficacy.
Language eng
DOI 10.1517/14728222.12.5.535
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2008
Copyright notice ©2008, Informa UK Ltd
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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