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Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution

Sharp, Julie A., Lefevre, Christophe and Nicholas, Kevin R. 2008, Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution, BMC biology, vol. 6, no. 48, pp. 1-15.

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Title Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution
Author(s) Sharp, Julie A.
Lefevre, Christophe
Nicholas, Kevin R.
Journal name BMC biology
Volume number 6
Issue number 48
Start page 1
End page 15
Publisher BioMed Central
Place of publication London, England
Publication date 2008
ISSN 1741-7007
Summary The mammary gland undergoes a sophisticated programme of developmental changes during pregnancy/lactation. However, little is known about processes involving initiation of apoptosis at involution following weaning. We used fur seals as models to study the molecular process of involution as these animals display a unique mammary gland phenotype. Fur seals have long lactation periods whereby mothers cycle between secreting copious quantities of milk for 2 to 3 days suckling pups on land, with trips to sea alone to forage for up to 23 days during which time mammary glands remain active without initiating apoptosis/involution.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2008, BioMed Central
Persistent URL http://hdl.handle.net/10536/DRO/DU:30017999

Document type: Journal Article
Collections: Institute of Biotechnology
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