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NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors

Foletta, Victoria, Prior, Matthew J., Stupka, Nicole, Carey, Kate, Segal, David, Jones, Sharon, Swinton, Courtney, Martin, Sheree, Cameron-Smith, David and Walder, Ken R. 2009, NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors, Journal of physiology, vol. 587, no. 7, pp. 1619-1634, doi: 10.1113/jphysiol.2008.167882.

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Title NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors
Author(s) Foletta, VictoriaORCID iD for Foletta, Victoria
Prior, Matthew J.
Stupka, Nicole
Carey, Kate
Segal, David
Jones, Sharon
Swinton, Courtney
Martin, Sheree
Cameron-Smith, David
Walder, Ken R.
Journal name Journal of physiology
Volume number 587
Issue number 7
Start page 1619
End page 1634
Total pages 16
Publisher Wiley-Blackwell
Place of publication Oxford, England
Publication date 2009-04
ISSN 0022-3751
Keyword(s) NDRG2
skeletal muscle
myoblast proliferation
Summary Skeletal muscle tissue undergoes adaptive changes in response to stress and the genes that control these processes are incompletely characterised. NDRG2 (N-myc downstream-regulated gene 2), a stress- and growth-related gene, was investigated in skeletal muscle growth and adaption. While NDRG2 expression levels were found to be up-regulated in both differentiated human and mouse myotubes compared with undifferentiated myoblasts, the suppression of NDRG2 in C2C12 myoblasts resulted in slowed myoblast proliferation. The increased expression levels of the cell cycle inhibitors, p21 Waf1/Cip1 and p27 Kip1, and of various muscle differentiation markers in NDRG2-deficient myoblasts indicate that a lack of NDRG2 promoted cell cycle exiting and the onset of myogenesis. Furthermore, the analysis of NDRG2 regulation in C2C12 myotubes treated with catabolic and anabolic agents and in skeletal muscle from human subjects following resistance exercise training revealed NDRG2 gene expression to be down-regulated during hypertrophic conditions, and conversely, up-regulated during muscle atrophy. Together, these data demonstrate that NDRG2 expression is highly responsive to different stress conditions in skeletal muscle and suggest that the level of NDRG2 expression may be critical to myoblast growth and differentiation.
Language eng
DOI 10.1113/jphysiol.2008.167882
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2009, The Authors.
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Created: Tue, 08 Sep 2009, 16:55:40 EST by Nicole Stupka

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