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Activation of the hypothalamo-pituitary-adrenal axis by isolation and restraint stress during lactation in ewes : effect of the presence of the lamb and suckling

Tilbrook, A. J., Turner, A. I., Ibbott, M. D. and Clarke, I. J. 2006, Activation of the hypothalamo-pituitary-adrenal axis by isolation and restraint stress during lactation in ewes : effect of the presence of the lamb and suckling, Endocrinology, vol. 147, no. 7, pp. 3501-3509, doi: 10.1210/en.2005-1632.

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Title Activation of the hypothalamo-pituitary-adrenal axis by isolation and restraint stress during lactation in ewes : effect of the presence of the lamb and suckling
Author(s) Tilbrook, A. J.
Turner, A. I.ORCID iD for Turner, A. I. orcid.org/0000-0002-0682-2860
Ibbott, M. D.
Clarke, I. J.
Journal name Endocrinology
Volume number 147
Issue number 7
Start page 3501
End page 3509
Publisher Published for the Endocrine Society by J.B. Lippincott
Place of publication Philadelphia, Pa.
Publication date 2006
ISSN 0013-7227
1945-7170
Summary We investigated the effect of the presence and absence of lambs and suckling by lambs to attenuate activation of the hypothalamo-pituitary-adrenal (HPA) axis to isolation and restraint stress in lactating sheep. In experiment 1, blood samples were collected every 10 min from nonlactating (n = 5) and lactating (n = 5) ewes for 4 h before and during stress. In experiment 2, ewes (n = 6) were allocated to 1) nonlactating, 2) lactating with lambs absent, 3) lactating with lambs present but unable to suckle, and 4) lactating with lambs present and able to suckle. Blood samples were collected over 8 h with no stress (control day) and for 4 h before and 4 h during stress (stress day). In experiment 1, the mean (±SEM) cortisol concentrations increased significantly (P < 0.05) in nonlactating ewes during stress but did not change in lactating ewes. In experiment 2, cortisol did not vary on the control day or pretreatment of the stress day but increased (P < 0.05) during stress in all groups except lactating ewes with lambs present and able to suckle. The greatest cortisol response occurred in nonlactating ewes followed by lactating ewes with lambs absent and lactating ewes with lambs present but unable to suckle. During stress, the ACTH concentrations increased (P < 0.05) in nonlactating ewes and lactating ewes with lambs absent but not in lactating ewes with lambs present. We conclude that the activity of the HPA axis during isolation and restraint is reduced in lactating ewes and that the presence of lambs increases this level of attenuation.
Language eng
DOI 10.1210/en.2005-1632
Field of Research 110306 Endocrinology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, The Endocrine Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30018616

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