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Nonribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptied bioeffectors - cyclosporin synthetase as a complex example

Velkov, Tony and Lawen, Alfons 2003, Nonribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptied bioeffectors - cyclosporin synthetase as a complex example, Biotechnology annual review, vol. 9, pp. 151-197.

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Title Nonribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptied bioeffectors - cyclosporin synthetase as a complex example
Author(s) Velkov, Tony
Lawen, Alfons
Journal name Biotechnology annual review
Volume number 9
Start page 151
End page 197
Publisher Elsevier
Place of publication Amsterdam, Netherlands
Publication date 2003
ISSN 1387-2656
1875-5208
Summary Many microbial peptide secondary metabolites possess important medicinal properties, of which the immunosuppressant cyclosporin A is an example. The enormous structural and functional diversity of these low-molecular weight peptides is attributable to their mode of biosynthesis. Peptide secondary metabolites are assembled non-ribosomally by multi-functional enzymes, termed non-ribosomal peptide synthetases. These systems consist of a multi-modular arrangement of the functional domains responsible for the catalysis of the partial reactions of peptide assembly. The extensive homology shared among NRPS systems allows for the generalisation of the knowledge garnered from studies of systems of diverse origins. In this review we shall focus the contemporary knowledge of non-ribosomal peptide biosynthesis on the structure and function of the cyclosporin biosynthetic system, with some emphasis on the re-direction of the biosynthetic potential of this system by combinatorial approaches.
Language eng
Field of Research 100299 Environmental Biotechnology not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019363

Document type: Journal Article
Collection: School of Medicine
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Created: Fri, 11 Sep 2009, 11:48:29 EST by Rachael Wilson

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