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Tissue distribution of lignans in rats in response to diet, dose−response, and competition with isoflavones

Murray, Timothy, Kang, Jinguo, Astheimer, Lee and Price, William E. 2007, Tissue distribution of lignans in rats in response to diet, dose−response, and competition with isoflavones, Journal of agricultural and food chemistry, vol. 55, no. 12, pp. 4907-4912, doi: 10.1021/jf070266q.

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Title Tissue distribution of lignans in rats in response to diet, dose−response, and competition with isoflavones
Author(s) Murray, Timothy
Kang, Jinguo
Astheimer, Lee
Price, William E.
Journal name Journal of agricultural and food chemistry
Volume number 55
Issue number 12
Start page 4907
End page 4912
Publisher American Chemical Society
Place of publication Columbus, Ohio
Publication date 2007
ISSN 0021-8561
1520-5118
Keyword(s) lignan
isoflavone
extraction
tissue
distribution
LC−ESI/MS
Summary This paper investigates the occurrence and distribution of the lignan metabolites enterodiol (END) and enterolactone (ENL) and the isoflavone daidzein (DAID) in rat tissues by use of liquid chromatography−electrospray ionization mass spectrometry (LC−ESI/MSn) following a variety of dietary regimes. Furthermore, we examined the dose−response and distribution of END and ENL in liver, testes, prostate, and lung, and we investigated the effects of competition between lignans and isoflavones on metabolite distribution. In liver, testes, prostate, and lung tissue, dose-related increases in END concentration were observed. In the testes, coadministration of 60 mg/kg secoisolariciresinol diglycoside (SDG) with 60 mg/kg isoflavones produced alterations in the resulting metabolite profile, causing increased END concentration and decreased DAID concentration. Results indicate lignan accumulation in tissues occurs, and coadministration of lignans with isoflavones affects the metabolite profile, with effects dependent on tissue type.
Language eng
DOI 10.1021/jf070266q
Field of Research 060299 Ecology not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, American Chemical Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019364

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor Research
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Created: Fri, 11 Sep 2009, 12:07:03 EST by Leanne Swaneveld

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