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The key importance of soy isoflavone bioavailability to understanding health benefits

Larkin, Theresa, Price, William E. and Astheimer, Lee 2008, The key importance of soy isoflavone bioavailability to understanding health benefits, Critical reviews in food science and nutrition, vol. 48, no. 6, pp. 538-552, doi: 10.1080/10408390701542716.

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Title The key importance of soy isoflavone bioavailability to understanding health benefits
Author(s) Larkin, Theresa
Price, William E.
Astheimer, Lee
Journal name Critical reviews in food science and nutrition
Volume number 48
Issue number 6
Start page 538
End page 552
Total pages 15
Publisher Taylor & Francis
Place of publication London, England
Publication date 2008-06
ISSN 1040-8398
1549-7852
Keyword(s) bioavailability
gut microbiota
soy isoflavones
equol
daidzein
genistein
Summary Research over the past two decades has provided significant epidemiological and other evidence for the health benefits of the consumption of soy-based foods. A large number of dietary intervention studies have examined the effects of soy isoflavones on risk factors for cardiovascular disease and hormone-dependent cancers. However, these report large variability in outcome measures, very limited reproducibility between studies, and in some cases, controversy between the results of clinical trials using dietary soy or soy protein and isoflavone supplementation. This highlights a major gap in our understanding of soy isoflavone uptake, metabolism, distribution, and overall bioavailability. There are many potential factors that may influence bioavailability and a better knowledge is necessary to rationalize the inconsistencies in the intervention and clinical studies. This review focuses attention on our current state of knowledge in this area and highlights the importance of metabolism of the parent soy isoflavones and the critical role of gut microbiota on the bioavailability of these compounds and their metabolites.
Language eng
DOI 10.1080/10408390701542716
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Taylor and Francis
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019381

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor Research
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