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Dietary combination of soy with a probiotic or prebiotic food significantly reduces total and LDL cholesterol in mildly hypercholesterolaemic subjects

Larkin, T. A., Astheimer, L. B. and Price, W. E. 2009, Dietary combination of soy with a probiotic or prebiotic food significantly reduces total and LDL cholesterol in mildly hypercholesterolaemic subjects, European journal of clinical nutrition, vol. 63, no. 2, pp. 238-245, doi: 10.1038/sj.ejcn.1602910.

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Title Dietary combination of soy with a probiotic or prebiotic food significantly reduces total and LDL cholesterol in mildly hypercholesterolaemic subjects
Author(s) Larkin, T. A.
Astheimer, L. B.
Price, W. E.
Journal name European journal of clinical nutrition
Volume number 63
Issue number 2
Start page 238
End page 245
Total pages 8
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2009-02
ISSN 0954-3007
1476-5640
Keyword(s) isoflavones
probiotic
prebiotic
lipids
bioavailability
equol
Summary Objective: We hypothesized that a dietary combination of soy with either a probiotic (yoghurt) or a prebiotic (resistant starch) would result in enhanced lipid-lowering effects compared with a control soy diet, possibly via improvements in isoflavone bioavailability.

Subjects: Mildly hypercholesterolaemic subjects (men and post-menopausal women) older than 45 years were recruited via the local media. Thirty-six subjects commenced the study; five withdrew.

Results: Soy+probiotic significantly decreased total cholesterol (4.72.0%; P=0.038) and soy+prebiotic significantly decreased total and low-density lipoprotein cholesterol (5.51.6%; P=0.003 and 7.32.2%; P=0.005, respectively). The bioavailabilities of daidzein, genistein or equol were not affected by probiotic or prebiotic consumption or associated with lipid changes.

Conclusion: Dietary combination of soy with either a probiotic or a prebiotic resulted in significant lipid lowering, not related to isoflavone bioavailability.
Notes published online 17 October 2007
Language eng
DOI 10.1038/sj.ejcn.1602910
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2009, Macmillan Publishers Limited
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019385

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor Research
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Created: Fri, 11 Sep 2009, 14:40:55 EST by Leanne Swaneveld

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