You are not logged in.

L-Arginine infusion increases glucose clearance during prolonged exercise in humans

McConell, G.K., Huynh, N. N., Lee-Young, R.S., Canny, B. J. and Wadley, G.D. 2006, L-Arginine infusion increases glucose clearance during prolonged exercise in humans, American journal of physiology : endocrinology and metabolism, vol. 290, no. 1, pp. E60-E66, doi: 10.1152/ajpendo.00263.2005.

Attached Files
Name Description MIMEType Size Downloads

Title L-Arginine infusion increases glucose clearance during prolonged exercise in humans
Author(s) McConell, G.K.
Huynh, N. N.
Lee-Young, R.S.
Canny, B. J.
Wadley, G.D.ORCID iD for Wadley, G.D.
Journal name American journal of physiology : endocrinology and metabolism
Volume number 290
Issue number 1
Start page E60
End page E66
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2006-01
ISSN 0193-1849
Keyword(s) nitric oxide
glucose kinetics
Summary Nitric oxide synthase (NOS) inhibition has been shown in humans to attenuate exercise-induced increases in muscle glucose uptake. We examined the effect of infusing the NO precursor L-arginine (L-Arg) on glucose kinetics during exercise in humans. Nine endurance-trained males cycled for 120 min at 72 ± 1% VO2 peak followed immediately by a 15-min "all-out" cycling performance bout. A [6,6-2H]glucose tracer was infused throughout exercise, and either saline alone (Control, CON) or saline containing L-Arg HCl (L-Arg, 30 g at 0.5 g/min) was coinfused in a double-blind, randomized order during the last 60 min of exercise. L-Arg augmented the increases in glucose rate of appearance, glucose rate of disappearance, and glucose clearance rate (L-Arg: 16.1 ± 1.8 ml·min–1·kg–1; CON: 11.9 ± 0.7 ml·min–1·kg–1 at 120 min, P < 0.05) during exercise, with a net effect of reducing plasma glucose concentration during exercise. L-Arg infusion had no significant effect on plasma insulin concentration but attenuated the increase in nonesterified fatty acid and glycerol concentrations during exercise. L-Arg infusion had no effect on cycling exercise performance. In conclusion, L-Arg infusion during exercise significantly increases skeletal muscle glucose clearance in humans. Because plasma insulin concentration was unaffected by L-Arg infusion, greater NO production may have been responsible for this effect.
Language eng
DOI 10.1152/ajpendo.00263.2005
Field of Research 110899 Medical Microbiology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, American Physiological Society
Persistent URL

Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 30 times in TR Web of Science
Scopus Citation Count Cited 37 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 532 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Tue, 15 Sep 2009, 16:02:43 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact