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L-Arginine infusion increases glucose clearance during prolonged exercise in humans

McConell, G.K., Huynh, N. N., Lee-Young, R.S., Canny, B. J. and Wadley, G.D. 2006, L-Arginine infusion increases glucose clearance during prolonged exercise in humans, American journal of physiology : endocrinology and metabolism, vol. 290, no. 1, pp. E60-E66, doi: 10.1152/ajpendo.00263.2005.

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Title L-Arginine infusion increases glucose clearance during prolonged exercise in humans
Author(s) McConell, G.K.
Huynh, N. N.
Lee-Young, R.S.
Canny, B. J.
Wadley, G.D.ORCID iD for Wadley, G.D. orcid.org/0000-0002-6617-4359
Journal name American journal of physiology : endocrinology and metabolism
Volume number 290
Issue number 1
Start page E60
End page E66
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2006-01
ISSN 0193-1849
1522-1555
Keyword(s) nitric oxide
glucose kinetics
contraction
Summary Nitric oxide synthase (NOS) inhibition has been shown in humans to attenuate exercise-induced increases in muscle glucose uptake. We examined the effect of infusing the NO precursor L-arginine (L-Arg) on glucose kinetics during exercise in humans. Nine endurance-trained males cycled for 120 min at 72 ± 1% VO2 peak followed immediately by a 15-min "all-out" cycling performance bout. A [6,6-2H]glucose tracer was infused throughout exercise, and either saline alone (Control, CON) or saline containing L-Arg HCl (L-Arg, 30 g at 0.5 g/min) was coinfused in a double-blind, randomized order during the last 60 min of exercise. L-Arg augmented the increases in glucose rate of appearance, glucose rate of disappearance, and glucose clearance rate (L-Arg: 16.1 ± 1.8 ml·min–1·kg–1; CON: 11.9 ± 0.7 ml·min–1·kg–1 at 120 min, P < 0.05) during exercise, with a net effect of reducing plasma glucose concentration during exercise. L-Arg infusion had no significant effect on plasma insulin concentration but attenuated the increase in nonesterified fatty acid and glycerol concentrations during exercise. L-Arg infusion had no effect on cycling exercise performance. In conclusion, L-Arg infusion during exercise significantly increases skeletal muscle glucose clearance in humans. Because plasma insulin concentration was unaffected by L-Arg infusion, greater NO production may have been responsible for this effect.
Language eng
DOI 10.1152/ajpendo.00263.2005
Field of Research 110899 Medical Microbiology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019472

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