Immunostimulatory principles from Chlorella pyrenoidosa – part 1 : isolation and biological assessment in vitro

Kralovec, J. A., Metera, K.L., Kumar, J. R., Watson, L. V., Girouard, G. S., Guan, Y., Carr, R. J., Barrow, C. J. and Ewart, H. S. 2007, Immunostimulatory principles from Chlorella pyrenoidosa – part 1 : isolation and biological assessment in vitro, Phytomedicine, vol. 14, no. 1, pp. 57-64.

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Title Immunostimulatory principles from Chlorella pyrenoidosa – part 1 : isolation and biological assessment in vitro
Formatted title Immunostimulatory principles from Chlorella pyrenoidosa – part 1 : isolation and biological assessment in vitro
Author(s) Kralovec, J. A.
Metera, K.L.
Kumar, J. R.
Watson, L. V.
Girouard, G. S.
Guan, Y.
Carr, R. J.
Barrow, C. J.
Ewart, H. S.
Journal name Phytomedicine
Volume number 14
Issue number 1
Start page 57
End page 64
Publisher G. Fischer
Place of publication Stuttgart, Germany
Publication date 2007-01-10
ISSN 0944-7113
1618-095X
Keyword(s) Chlorella extract
bioassay-guided fractionation
immunostimulatory
B cells
macrophages
Summary Our proprietary preparation obtained by extraction of Chlorella pyrenoidosa cells, ONC-107 (Respondin™), was recently found to selectively boost antibody response to the influenza vaccine in a human clinical trial. Respondin™ is a potent stimulator of mouse B cell proliferation and an activator of macrophages. Bioactivity-guided resolution concluded that Respondin™ is composed of a mixture of immunostimulatory principles of different chemical nature. A combination of size exclusion, anion exchange and hydrophobic interaction chromatography revealed that the bulk of the immunostimulatory activity resides in polysaccharide/protein complexes with molecular masses larger than 100 kDa that are composed primarily of galactose, rhamnose and arabinose.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019501

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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