Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific — redefining platelet response to fish oils

Phang, Melinda, Garg, Manohar L. and Sinclair, Andrew J. 2009, Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific — redefining platelet response to fish oils, Prostaglandins, leukotrienes and essential fatty acids, vol. 81, no. 1, pp. 35-40.

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Title Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific — redefining platelet response to fish oils
Author(s) Phang, Melinda
Garg, Manohar L.
Sinclair, Andrew J.
Journal name Prostaglandins, leukotrienes and essential fatty acids
Volume number 81
Issue number 1
Start page 35
End page 40
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2009-07
ISSN 0952-3278
1532-2823
Keyword(s) platelet aggregation
gender
inhibition
LCn-3 PUFA
docosahexaenoic acid
eicosapentaenoic acid
Summary Existence of gender differences in cardiovascular disease (CVD) following long-chain omega-3 polyunsaturated fatty acid (LCn-3 PUFA) supplementation have suggested that sex hormones play a role in cardio-protection. The objective of this study was to determine gender specific responses in the efficacy of LCn-3 PUFA to inhibit platelet aggregation in vitro. Blood was analyzed for collagen-induced platelet aggregation following pre-incubation with LCn-3 PUFA in healthy adults (n=42). Eicosapentaenoic acid (EPA) was significantly more effective in reducing platelet aggregation compared with docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA). When grouped by gender, this differential pattern was followed in males only. In females, DHA, DPA and EPA were all equally effective. Between group analyses (LCn-3 PUFA vs. gender) showed that both DHA and DPA were significantly less effective in males compared with females. EPA was equally effective in reducing platelet aggregation in both groups. These findings show that significant gender differences exist in platelet aggregation in response to various LCn-3 PUFA treatments.
Language eng
Field of Research 110107 Metabolic Medicine
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2009, Elsevier Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019542

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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