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Method design and validation for the determination of uranium levels in human urine using high-resolution alpha spectrometry

Manickam, E., Sdraulig, S. and Tinker, R.A. 2008, Method design and validation for the determination of uranium levels in human urine using high-resolution alpha spectrometry, Journal of environmental radioactivity, vol. 99, no. 3, pp. 491-501, doi: 10.1016/j.jenvrad.2007.08.008.

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Title Method design and validation for the determination of uranium levels in human urine using high-resolution alpha spectrometry
Author(s) Manickam, E.
Sdraulig, S.
Tinker, R.A.
Journal name Journal of environmental radioactivity
Volume number 99
Issue number 3
Start page 491
End page 501
Publisher Elservier Ltd.
Place of publication Amsterdam, Netherlands
Publication date 2008-03
ISSN 0265-931X
1879-1700
Keyword(s) uranium human urine
high-resolution alpha spectrometry
method design and validation
Summary Quantification of uranium in human urine is a valuable technique for assessing occupational and public exposure to uranium. A reliable method has been developed and validated in the ARPANSA Radiochemistry Laboratory by means of standard radiochemical separation and purification techniques and measurement using high-resolution alpha spectrometry. This method can be used to evaluate the levels of naturally occurring 234U, 235U and 238U in urine. Method design and validation is the process of defining an analytical requirement, and then confirming that the method under consideration has performance capabilities consistent with what the application requires. The method was designed to measure levels down to 2 mBq/day of total uranium, corresponding to approximately 1/100th of the annual committed effective dose of 20 mSv. Validation tests were developed to assess selectivity, accuracy, recovery and quantification of uncertainty. The radiochemical recovery of this method was measured using 232U tracer. The typical minimum detectable concentration for total uranium for 24-h urine samples is approximately 0.6 mBq/day or 0.019 μg/day.
Language eng
DOI 10.1016/j.jenvrad.2007.08.008
Field of Research 110199 Medical Biochemistry and Metabolomics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
HERDC collection year 2008
Copyright notice ©2008, Elsevier Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019547

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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Created: Wed, 16 Sep 2009, 15:41:05 EST by Lorraine Driscoll

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