Estimation of the dietary requirement for vitamin D in healthy adults

Cashman, Kevin D, Hill, Tom R, Lucey, Alice J, Taylor, Nicola, Seamans, Kelly M, Muldowney, Siobhan, FitzGerald, Anthony P, Flynn, Albert, Barnes, Maria S, Horigan, Geraldine, Bonham, Maxine P, Duffy, Emeir M, Strain, JJ, Wallace, Julie MW and Kiely, Mairead 2008, Estimation of the dietary requirement for vitamin D in healthy adults, American journal of clinical nutrition, vol. 88, no. 6, pp. 1535-1542, doi: 10.3945/ajcn.2008.26594.

Attached Files
Name Description MIMEType Size Downloads

Title Estimation of the dietary requirement for vitamin D in healthy adults
Author(s) Cashman, Kevin D
Hill, Tom R
Lucey, Alice J
Taylor, Nicola
Seamans, Kelly M
Muldowney, Siobhan
FitzGerald, Anthony P
Flynn, Albert
Barnes, Maria S
Horigan, Geraldine
Bonham, Maxine P
Duffy, Emeir M
Strain, JJ
Wallace, Julie MW
Kiely, Mairead
Journal name American journal of clinical nutrition
Volume number 88
Issue number 6
Start page 1535
End page 1542
Publisher American Society for Nutrition
Place of publication New York, N.Y.
Publication date 2008-12
ISSN 0002-9165
Summary Background: Knowledge gaps have contributed to considerable variation among international dietary recommendations for vitamin D.

We aimed to establish the distribution of dietary vitamin D required to maintain serum 25-hydroxyvitamin D [25(OH)D] concentrations above several proposed cutoffs (ie, 25, 37.5, 50, and 80 nmol/L) during wintertime after adjustment for the effect of summer sunshine exposure and diet.

Design: A randomized, placebo-controlled, double-blind 22-wk intervention study was conducted in men and women aged 20–40 y (n = 238) by using different supplemental doses (0, 5, 10, and 15 µg/d) of vitamin D3 throughout the winter. Serum 25(OH)D concentrations were measured by using enzyme-linked immunoassay at baseline (October 2006) and endpoint (March 2007).

Results: There were clear dose-related increments (P < 0.0001) in serum 25(OH)D with increasing supplemental vitamin D3. The slope of the relation between vitamin D intake and serum 25(OH)D was 1.96 nmol·L–1·µg–1 intake. The vitamin D intake that maintained serum 25(OH)D concentrations of >25 nmol/L in 97.5% of the sample was 8.7 µg/d. This intake ranged from 7.2 µg/d in those who enjoyed sunshine exposure, 8.8 µg/d in those who sometimes had sun exposure, and 12.3 µg/d in those who avoided sunshine. Vitamin D intakes required to maintain serum 25(OH)D concentrations of >37.5, >50, and >80 nmol/L in 97.5% of the sample were 19.9, 28.0, and 41.1 µg/d, respectively.

Conclusion: The range of vitamin D intakes required to ensure maintenance of wintertime vitamin D status [as defined by incremental cutoffs of serum 25(OH)D] in the vast majority (>97.5%) of 20–40-y-old adults, considering a variety of sun exposure preferences, is between 7.2 and 41.1 µg/d.
Language eng
DOI 10.3945/ajcn.2008.26594
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
HERDC collection year 2008
Copyright notice ©2008, American Society for Nutrition
Persistent URL

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 150 times in TR Web of Science
Scopus Citation Count Cited 168 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 400 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Thu, 17 Sep 2009, 10:13:50 EST by Lorraine Driscoll

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact