Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study

Wallace, Julie M.W., Bonham, Maxine P, Strain, JJ, Duffy, Emeir M, Robson, Paula J., Ward, Mary, McNulty, Helene, Davidson, Philip W., Myers, Gary J., Shamlaye, Conrad F., Clarkson, Thomas W., Molloy, Anne M., Scott, John M. and Ueland, Per M 2008, Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study, American journal of clinical nutrition, vol. 87, no. 2, pp. 391-397.

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Title Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study
Author(s) Wallace, Julie M.W.
Bonham, Maxine P
Strain, JJ
Duffy, Emeir M
Robson, Paula J.
Ward, Mary
McNulty, Helene
Davidson, Philip W.
Myers, Gary J.
Shamlaye, Conrad F.
Clarkson, Thomas W.
Molloy, Anne M.
Scott, John M.
Ueland, Per M
Journal name American journal of clinical nutrition
Volume number 87
Issue number 2
Start page 391
End page 397
Publisher American Society for Clinical Nutrition
Place of publication New York, N.Y.
Publication date 2008-02
ISSN 0002-9165
1938-3207
Keyword(s) homocysteine
folate
betaine
vitamin B-12
pregnancy
maternal status
Summary Background: Both folate and betaine are important predictors of total homocysteine (tHcy) during pregnancy. However, studies to date have only been undertaken in populations with Western dietary patterns.

Objective: We investigated the predictors of tHcy in pregnant women recruited in the Seychelles, a population where access to fortified foods is limited and where women habitually consume diets rich in fish, eggs, rice, and fruit.

Design: Pregnant women (n = 226) provided blood samples at enrollment, at week 28 of gestation, and at delivery. Cord blood was obtained from a subset of participants (n = 135).

Results:
As in other studies, maternal tHcy was lower during pregnancy than at delivery, whereas folate and vitamin B-12 status declined significantly to delivery. Despite low maternal folate status at delivery (median: 9.0 nmol/L), with 35% of women in the deficient range (serum folate: <6.8 nmol/L), cord blood folate status (median: 40.2 nmol/L) was similar to concentrations reported in Western populations. Folate was a significant predictor of tHcy at all time points (P < 0.001). In contrast with previous studies, betaine was only a significant predictor of maternal tHcy (P < 0.001) when the essential amino acid methionine was low.

Conclusions: The current study reports 2 important findings. First, fetal requirements for folate are paramount, such that cord blood folate status is maintained, even when maternal status is low. Second, betaine is a significant predictor of tHcy in pregnant women with low serum folate and low serum methionine concentrations.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
HERDC collection year 2008
Copyright notice ©2008, American Society for Nutrition
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019606

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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Created: Thu, 17 Sep 2009, 15:53:16 EST by Lorraine Driscoll

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