Cortisol disrupts the ability of estradiol-17β to induce the LH surge in ovariectomized ewes

Pearce, B. N., Clarke, I. J., Turner, A. I., Rivalland, E. T. A. and Tilbrook, A. J. 2009, Cortisol disrupts the ability of estradiol-17β to induce the LH surge in ovariectomized ewes, Domestic animal endocrinology, vol. 36, no. 4, pp. 202-208, doi: 10.1016/j.domaniend.2008.11.003.

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Title Cortisol disrupts the ability of estradiol-17β to induce the LH surge in ovariectomized ewes
Author(s) Pearce, B. N.
Clarke, I. J.
Turner, A. I.ORCID iD for Turner, A. I.
Rivalland, E. T. A.
Tilbrook, A. J.
Journal name Domestic animal endocrinology
Volume number 36
Issue number 4
Start page 202
End page 208
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2009-05
ISSN 0739-7240
Keyword(s) cortisol
LH surge
Summary Stress disrupts the preovulatory luteinizing hormone (LH) surge in females, but the mechanisms are unknown. We tested the hypothesis that cortisol compromises the ability of estrogen to induce a preovulatory-like LH surge in ovariectomized ewes in both the breeding and nonbreeding season. Luteinizing hormone surges were induced in ovariectomized ewes by treatment with progesterone followed by a surge-inducing estradiol-17β (E2) stimulus using a crossover design. The experiment was replicated in the breeding and nonbreeding seasons. Cortisol reduced the incidence of LH surges irrespective of season. Cortisol increased the latency from E2 stimulus to the onset of the surge in the breeding season only and suppressed the LH surge amplitude during both seasons (P < 0.01). We conclude that cortisol can interfere with the LH surge in several ways: delay, blunt, and in extreme cases prevent the E2-induced LH surge. Furthermore, the effect of cortisol to delay the E2-induced LH surge is more pronounced in the breeding season. These results show that cortisol disrupts the positive feedback effect of E2 to trigger an LH surge and suggest the involvement of multiple mechanisms.
Language eng
DOI 10.1016/j.domaniend.2008.11.003
Field of Research 110306 Endocrinology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2009
Copyright notice ©2008, Elsevier Inc
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