Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

Barnes, M.S., Robson, P.J., Bonham, M.P., Strain, JJ and Wallace, J.M.W 2006, Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults, European journal of clinical nutrition, vol. 60, no. 6, pp. 727-733, doi: 10.1038/sj.ejcn.1602374.

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Title Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults
Author(s) Barnes, M.S.
Robson, P.J.
Bonham, M.P.
Strain, JJ
Wallace, J.M.W
Journal name European journal of clinical nutrition
Volume number 60
Issue number 6
Start page 727
End page 733
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2006-06
ISSN 0954-3007
Keyword(s) 25-hydroxyvitamin D
vitamin D deficiency
dietary intake
vitamin D supplementation
bone turnover
Summary Objective: To assess the vitamin D status of healthy young people living in Northern Ireland and the effect of vitamin D supplementation on vitamin D status and bone turnover.

Design: Double-blinded randomised controlled intervention study.

Setting: University of Ulster, Coleraine, Northern Ireland.

Subjects: In total, 30 apparently healthy students (15 male and 15 female subjects), aged 18–27 years, were recruited from the university, with 27 completing the intervention.

Interventions: Subjects were randomly assigned, to receive either 15 mug (600 IU) vitamin D3 and 1500 mg calcium/day (vitamin D group), or 1500 mg calcium/day (control group) for 8 weeks between January and March. Vitamin D status, bone turnover markers, serum calcium and parathyroid hormone concentrations were measured at baseline and post intervention.

Results: At baseline, vitamin D status was low in both the vitamin D group (47.9 (s.d. 16.0)) and the control group (55.5 (s.d. 18.6) nmol/l 25(OH)D). Post intervention vitamin D status was significantly higher in the vitamin D-treated group (86.5 (s.d. 24.5)) compared to the control group (48.3 (s.d. 16.8) nmol/l) (P<0.0001). There was no significant effect of supplementation on bone turnover markers or PTH concentrations.

Conclusions: This study suggests that young adults in Northern Ireland do not consume an adequate daily dietary intake of vitamin D to maintain plasma vitamin D concentrations in the wintertime. A daily supplement of 15 mug vitamin D3 significantly increased vitamin D status in these individuals to levels of sufficiency. Achievement of an optimum vitamin D status among young adults may have future positive health implications.
Language eng
DOI 10.1038/sj.ejcn.1602374
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019641

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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