Effect of zinc supplementation on the immune status of healthy older individuals aged 55–70 years : the ZENITH Study

Hodkinson, Clare F., Kelly, Mary, Alexander, H. Denis, Bradbury, Ian, Robson, Paula J., Bonham, Maxine P, O'Connor, Jacqueline M., Coudray, Charles, Strain, JJ and Wallace, Julie M.W. 2007, Effect of zinc supplementation on the immune status of healthy older individuals aged 55–70 years : the ZENITH Study, The journals of gerontology. series A, biological sciences and medical sciences, vol. 62A, no. 6, pp. 598-608.

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Title Effect of zinc supplementation on the immune status of healthy older individuals aged 55–70 years : the ZENITH Study
Author(s) Hodkinson, Clare F.
Kelly, Mary
Alexander, H. Denis
Bradbury, Ian
Robson, Paula J.
Bonham, Maxine P
O'Connor, Jacqueline M.
Coudray, Charles
Strain, JJ
Wallace, Julie M.W.
Journal name The journals of gerontology. series A, biological sciences and medical sciences
Volume number 62A
Issue number 6
Start page 598
End page 608
Publisher Oxford University Press
Place of publication Cary, N.C.
Publication date 2007-06
ISSN 1079-5006
1758-535X
Keyword(s) b-lymphocytes
biological markers
CD4-CD8 ratio
dietary supplements
zinc
diet supplementation
Summary Aging is associated with alterations in the immune system, effects which may be exacerbated by inadequate zinc (Zn) status. We examined the relationship between Zn status and markers of immunity and the effect of supplementation with 15 mg or 30 mg Zn/d for 6 months on immune status in healthy individuals. Zn status was assessed by dietary intake and biochemical indices. Immune status was assessed by multiple flow cytometric methods. At baseline, Zn concentration was positively associated with lymphocyte subpopulation counts and T-lymphocyte activation. Zn supplementation of 30 mg/d significantly lowered B-lymphocyte count, albeit at month 3 only. Lower doses of Zn (15 mg Zn/d) significantly increased the ratio of CD4 to CD8 T lymphocytes at month 6. Overall, these findings suggest that total Zn intake (diet plus supplementation) of up to 40 mg Zn/d do not have significant long-term effects on immune status in apparently healthy persons aged 55–70 years.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2007, The Gerontological Society of America
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019645

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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