Whole blood analysis of phagocytosis, apoptosis, cytokine production, and leukocyte subsets in healthy older men and women: the ZENITH study

Hodkinson, Clare F., O'Connor, Jacqueline M., Alexander, H. Denis, Bradbury, Ian, Bonham, Maxine P, Hannigan, Bernadette M., Gilmore, William S., Strain, JJ and Wallace, Julie M.W. 2006, Whole blood analysis of phagocytosis, apoptosis, cytokine production, and leukocyte subsets in healthy older men and women: the ZENITH study, The journals of gerontology. series A, biological sciences and medical sciences, vol. 61A, no. 9, pp. 907-917.

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Title Whole blood analysis of phagocytosis, apoptosis, cytokine production, and leukocyte subsets in healthy older men and women: the ZENITH study
Author(s) Hodkinson, Clare F.
O'Connor, Jacqueline M.
Alexander, H. Denis
Bradbury, Ian
Bonham, Maxine P
Hannigan, Bernadette M.
Gilmore, William S.
Strain, JJ
Wallace, Julie M.W.
Journal name The journals of gerontology. series A, biological sciences and medical sciences
Volume number 61A
Issue number 9
Start page 907
End page 917
Publisher Oxford University Press
Place of publication Cary, N.C.
Publication date 2006-09
ISSN 1079-5006
1758-535X
Keyword(s) age distribution
aging
apoptosis
antigens
t-lymphocyte
apoptosis
c-reactive protein
complement C3
complement C4
HLA-DR antigens
interleukin-1
Summary Few studies to date have examined age-related changes in markers of immune status in healthy older individuals. The immune status of 93 healthy individuals aged 55–70 years was assessed by two- and three-color flow cytometry and biochemical analysis. There were significant age effects (p ≤.05) on monocyte phagocytic activity and cluster of differentiation (CD) 3/human leukocyte antigen-D-related (HLA-DR) late-activated T lymphocytes (% expression). There was a significant (p ≤ 0.1) Age x Sex interaction in absolute counts (x 109/L) of CD3/CD8 total cytotoxic T lymphocytes (CTL), the CD4 T- helper to CD8 CTL ratio, the CD3/CD4/CD45RA naïve T helper to CD3/CD4/CD45RO memory T helper lymphocyte ratio, and interleukin (IL)-1ß (% expression) by activated monocytes. The study shows that alterations in markers of immune status occur between 55 and 70 years, and provides reference values for the lymphocyte measures in healthy men and postmenopausal women in this age group. The study further highlights the need for sex-specific reference ranges for such markers.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2006, The Gerontological Society of America
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019648

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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