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Cortisol interferes with the estradiol-induced surge of lutenizing hormone in the ewe

Wagenmaker, Elizabeth R., Breen, Kellie M., Oakley, Amy E., Pierce, Bree N., Tilbrook, Alan J., Turner, Anne I. and Karsch, Fred J. 2009, Cortisol interferes with the estradiol-induced surge of lutenizing hormone in the ewe, Biology of reproduction, vol. 80, no. 3, pp. 458-463.

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Title Cortisol interferes with the estradiol-induced surge of lutenizing hormone in the ewe
Author(s) Wagenmaker, Elizabeth R.
Breen, Kellie M.
Oakley, Amy E.
Pierce, Bree N.
Tilbrook, Alan J.
Turner, Anne I.ORCID iD for Turner, Anne I. orcid.org/0000-0002-0682-2860
Karsch, Fred J.
Journal name Biology of reproduction
Volume number 80
Issue number 3
Start page 458
End page 463
Total pages 6
Publisher Society for the Study of Reproduction
Place of publication Champaign, Ill.
Publication date 2009-03
ISSN 0006-3363
0523-6754
1529-7268
Keyword(s) cortisol
estradiol
glucocorticoid
LH surge
luteinizing hormone
positive feedback
stress
Summary Two experiments were conducted to test the hypothesis that cortisol interferes with the positive feedback action of estradiol that induces the luteinizing hormone (LH) surge. Ovariectomized sheep were treated sequentially with progesterone and estradiol to create artificial estrous cycles. Cortisol or vehicle (saline) was infused from 2 h before the estradiol stimulus through the time of the anticipated LH surge in the artificial follicular phase of two successive cycles. The plasma cortisol increment produced by infusion was ∼1.5 times greater than maximal concentrations seen during infusion of endotoxin, which is a model of immune/inflammatory stress. In experiment 1, half of the ewes received vehicle in the first cycle and cortisol in the second; the others were treated in reverse order. All ewes responded with an LH surge. Cortisol delayed the LH surge and reduced its amplitude, but both effects were observed only in the second cycle. Experiment 2 was modified to provide better control for a cycle effect. Four treatment sequences were tested (cycle 1-cycle 2): vehicle-vehicle, cortisol-cortisol, vehicle-cortisol, cortisol-vehicle. Again, cortisol delayed but did not block the LH surge, and this delay occurred in both cycles. Thus, an elevation in plasma cortisol can interfere with the positive feedback action of estradiol by delaying and attenuating the LH surge.
Language eng
Field of Research 110306 Endocrinology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2009
Copyright notice ©2009, Society for the Study of Reproduction
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019650

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.