Regulation of STARS and its downstream target suggest a novel pathway involved in human skeletal hypertrophy and atrophy

Lamon, Severine, Wallace, Marita A., Leger, Bertrand and Russell, Aaron P. 2009, Regulation of STARS and its downstream target suggest a novel pathway involved in human skeletal hypertrophy and atrophy, Journal of physiology, vol. 587, no. 8, pp. 1795-1803.

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Title Regulation of STARS and its downstream target suggest a novel pathway involved in human skeletal hypertrophy and atrophy
Author(s) Lamon, Severine
Wallace, Marita A.
Leger, Bertrand
Russell, Aaron P.
Journal name Journal of physiology
Volume number 587
Issue number 8
Start page 1795
End page 1803
Publisher Wiley-Blackwell
Place of publication Oxford, England
Publication date 2009-04-15
ISSN 0022-3751
1469-7793
Summary Skeletal muscle atrophy is a severe consequence of ageing, neurological disorders and chronic disease. Identifying the intracellular signalling pathways controlling changes in skeletal muscle size and function is vital for the future development of potential therapeutic interventions. Striated activator of Rho signalling (STARS), an actin-binding protein, has been implicated in rodent cardiac hypertrophy; however its role in human skeletal muscle has not been determined. This study aimed to establish if STARS, as well as its downstream signalling targets, RhoA, myocardin-related transcription factors A and B (MRTF-A/B) and serum response factor (SRF), were increased and decreased respectively, in human quadriceps muscle biopsies taken after 8 weeks of both hypertrophy-stimulating resistance training and atrophy-stimulating de-training. The mRNA levels of the SRF target genes involved in muscle structure, function and growth, such as α-actin, myosin heavy chain IIa (MHCIIa) and insulin-like growth factor-1 (IGF-1), were also measured. Following resistance training, STARS, MRTF-A, MRTF-B, SRF, α-actin, MHCIIa and IGF-1 mRNA, as well as RhoA and nuclear SRF protein levels were all significantly increased by between 1.25- and 3.6-fold. Following the de-training period all measured targets, except for RhoA, which remained elevated, returned to base-line. Our results show that the STARS signalling pathway is responsive to changes in skeletal muscle loading and appears to play a role in both human skeletal muscle hypertrophy and atrophy.
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Language eng
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2009
Copyright notice ©2009, Wiley-Blackwell
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019659

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