Covalent immobilization of naringinase for the transformation of a flavonoid
Puri, Munish, Kaur, Harsimran and Kennedy, John F. 2005, Covalent immobilization of naringinase for the transformation of a flavonoid, Journal of chemical technology and biotechnology, vol. 80, no. 10, pp. 1160-1165.
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Covalent immobilization of naringinase for the transformation of a flavonoid
Naringinase (EC 3.2.1.40) from Penicillium sp was immobilized by covalent binding to woodchips to improve its catalytic activity. The immobilization of naringinase on glutaraldehyde-coated woodchips (600 mg woodchips, 10 U naringinase, 45 °C, pH 4.0 and 12h) through 1% glutaraldehyde cross-linking was optimized. The pH-activity curve of the immobilized enzyme shifted toward a lower pH compared with that of the soluble enzyme. The immobilization caused a marked increase in thermal stability of the enzyme. The immobilized naringinase was stable during storage at 4 °C. No loss of activity was observed when the immobilized enzyme was used for seven consecutive cycles of operations. The efficiency of immobilization was 120%, while soluble naringinase afforded 82% efficacy for the hydrolysis of standard naringin under optimal conditions. Its applicability for debittering kinnow mandarin juice afforded 76% debittering efficiency.
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eng
Field of Research
100301 Biocatalysis and Enzyme Technology 100302 Bioprocessing, Bioproduction and Bioproducts