Low-dose metronomic paclitaxel chemotherapy suppresses breast tumors and metastases in mice

Jiang, Hongchi, Tao, Weiyang, Zhang, Mu, Pan, Shangha, Kanwar, Jagat and Sun, Xueying 2010, Low-dose metronomic paclitaxel chemotherapy suppresses breast tumors and metastases in mice, Cancer investigation, vol. 28, no. 1, pp. 74-84.

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Title Low-dose metronomic paclitaxel chemotherapy suppresses breast tumors and metastases in mice
Author(s) Jiang, Hongchi
Tao, Weiyang
Zhang, Mu
Pan, Shangha
Kanwar, Jagat
Sun, Xueying
Journal name Cancer investigation
Volume number 28
Issue number 1
Start page 74
End page 84
Publisher Informa Healthcare
Place of publication New York, N.Y.
Publication date 2010
ISSN 0735-7907
1532-4192
Summary This study investigated the use of low-dose metronomic (LDM) chemotherapy with paclitaxel in a highly metastatic mouse model of 4T1 breast cancers, and compared it with the maximum tolerable dose (MTD) therapy. LDM therapy displayed a stronger anti-tumor activity in suppressing primary and metastatic breast tumors with less degree of side effects, and stronger anti-angiogenic and anti-lymphangiogenic activities than MTD therapy. But MTD therapy showed stronger pro-apoptotic and anti-proliferative activities in situ. Paclitaxel therapy downregulated expression of vascular endothelial growth factor receptor-2 (VEGFR2) and up-regulated expression of thrombospondin-1. The results support the application of paclitaxel LDM therapy to treat advanced breast cancer.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, Informa Healthcare USA
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019763

Document type: Journal Article
Collection: Institute of Biotechnology
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