α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans

Brenna, J. Thomas, Salem Jr., Norman, Sinclair, Andrew J. and Cunnane, Stephen C. 2009, α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans, Prostaglandins, leukotrienes and essential fatty acids, vol. 80, no. 2-3, pp. 85-91.

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Title α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans
Author(s) Brenna, J. Thomas
Salem Jr., Norman
Sinclair, Andrew J.
Cunnane, Stephen C.
Journal name Prostaglandins, leukotrienes and essential fatty acids
Volume number 80
Issue number 2-3
Start page 85
End page 91
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2009-02
ISSN 0952-3278
1532-2823
Keyword(s) ISSFAL Statement
Omega-3 fatty acid supplementation
Human PUFA nutrition
Summary Blood levels of polyunsaturated fatty acids (PUFA) are considered biomarkers of status. Alpha-linolenic acid, ALA, the plant omega-3, is the dietary precursor for the long-chain omega-3 PUFA eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Studies in normal healthy adults consuming western diets, which are rich in linoleic acid (LA), show that supplemental ALA raises EPA and DPA status in the blood and in breast milk. However, ALA or EPA dietary supplements have little effect on blood or breast milk DHA levels, whereas consumption of preformed DHA is effective in raising blood DHA levels. Addition of ALA to the diets of formula-fed infants does raise DHA, but no level of ALA tested raises DHA to levels achievable with preformed DHA at intakes similar to typical human milk DHA supply. The DHA status of infants and adults consuming preformed DHA in their diets is, on average, greater than that of people who do not consume DHA. With no other changes in diet, improvement of blood DHA status can be achieved with dietary supplements of preformed DHA, but not with supplementation of ALA, EPA, or other precursors.
Language eng
Field of Research 110107 Metabolic Medicine
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2009, Elsevier Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019819

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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