Long-term effect of calcium-vitamin D3 fortified milk on blood pressure and serum lipid concenstrations in healthy older men

Daly, Robin and Nowson, Caryl 2009, Long-term effect of calcium-vitamin D3 fortified milk on blood pressure and serum lipid concenstrations in healthy older men, European journal of clinical nutrition, vol. 63, no. 8, pp. 993-1000, doi: 10.1038/ejcn.2008.79.

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Title Long-term effect of calcium-vitamin D3 fortified milk on blood pressure and serum lipid concenstrations in healthy older men
Author(s) Daly, RobinORCID iD for Daly, Robin orcid.org/0000-0002-9897-1598
Nowson, CarylORCID iD for Nowson, Caryl orcid.org/0000-0001-6586-7965
Journal name European journal of clinical nutrition
Volume number 63
Issue number 8
Start page 993
End page 1000
Total pages 8
Publisher Nature Publishing Group
Place of publication Basingstoke, England
Publication date 2009
ISSN 0954-3007
Keyword(s) blood pressure
calcium-vitamin D3
fortified milk
Summary Background/Objectives:
Some epidemiological and clinical studies have shown that increased dairy consumption or calcium and/or vitamin D supplementation can have a beneficial effect on blood pressure, and lipid and lipoprotein concentrations. The aim of this study was to assess the long-term effects of calcium-vitamin D3 fortified milk on blood pressure and lipid-lipoprotein concentrations in community-dwelling older men.

This is a substudy of a 2-year randomized controlled trial in which 167 men aged >50 years were assigned to receive either 400 ml per day of reduced fat (approx1%) milk fortified with approximately 1000 mg of calcium and 800 IU of vitamin D3 or to a control group receiving no additional fortified milk. Weight, blood pressure, lipid and lipoprotein concentrations were measured every 6 months. Participants on lipid-lowering (n=32) or antihypertensive medication (n=39) were included, but those who commenced, increased or decreased their medication throughout the intervention were excluded (n=27).

In the 140 men included in this study (milk, n=73; control, n=67), there were no significant effects of the calcium-vitamin D3 fortified milk on weight, systolic or diastolic blood pressure, total cholesterol, high-density lipoprotein or low-density lipoprotein cholesterol or triglyceride concentrations at any time throughout the intervention. Similar results were observed after excluding men taking antihypertensive or lipid-lowering medication or limiting the analysis to those with baseline calcium intakes <1000 mg per day and/or with hypovitaminosis D (25(OH)D <75 nmol/l).

Supplementation with reduced-fat calcium-vitamin D3 fortified milk did not have a beneficial (nor detrimental) effect on blood pressure, lipid or lipoprotein concentrations in healthy community-dwelling older men.
Notes Published online 21 January 2009
Language eng
DOI 10.1038/ejcn.2008.79
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1 Refereed article in a scholarly journal
Grant ID NHMRC 425849
Copyright notice ©2009, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019891

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