Suppressors of cytokine signaling : functions in normal biology and roles in disease

Ward, Alister C, Barry, Anna and O'Sullivan, Lynda A 2009, Suppressors of cytokine signaling : functions in normal biology and roles in disease, in Jak-stat pathway in disease, Landes Bioscience, Austin, Tex., pp.10-23.

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Title Suppressors of cytokine signaling : functions in normal biology and roles in disease
Author(s) Ward, Alister C
Barry, Anna
O'Sullivan, Lynda A
Title of book Jak-stat pathway in disease
Editor(s) Stephanou, Anastasis
Publication date 2009
Series Medical intelligence unit (Unnumbered : 2003)
Chapter number 2
Total chapters 12
Start page 10
End page 23
Total pages 14
Publisher Landes Bioscience
Place of Publication Austin, Tex.
Keyword(s) suppressor of cytokine signaling
SaCS
cytokine
Summary Suppressor of cytokine signaling (SaCS) proteins have been identified as key negative regulators of cytokine and growth factor signaling. Therefore, given the diverse roles played by cytokines and growth factors in development and disease, it is not surprising that the sacs proteins themselves possess equally diverse and important functions, such as the control of hematopoiesis, immune function, growth and placental development. Significantly, more recent studies are increaSingly highlighting the crucial roles played by SOCS proteins in disease, particularly their tumor suppressor and anti-infammatory functions. Collectively, this research has served to confirm the importance of this class of proteins and suggests that therapeutic strategies for modulating SOCS proteins might be relevant for a range of diseases.
ISBN 9781587063152
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category B1 Book chapter
HERDC collection year 2009
Copyright notice ©2009, Landes Bioscience
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019945

Document type: Book Chapter
Collection: School of Medicine
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