Chromium(III)-docosahexaenoic acid complex : synthesis and characterization

Kralovec, Jaroslav A., Potvin, Michael A., Wright, Jeffrey H. D., Watson, Lynn V., Ewart, H. Stephen, Curtis, Jonathan M. and Barrow, Colin J. 2009, Chromium(III)-docosahexaenoic acid complex : synthesis and characterization, Journal of functional foods, vol. 1, no. 3, pp. 291-297, doi: 10.1016/j.jff.2009.06.001.

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Title Chromium(III)-docosahexaenoic acid complex : synthesis and characterization
Author(s) Kralovec, Jaroslav A.
Potvin, Michael A.
Wright, Jeffrey H. D.
Watson, Lynn V.
Ewart, H. Stephen
Curtis, Jonathan M.
Barrow, Colin J.ORCID iD for Barrow, Colin J.
Journal name Journal of functional foods
Volume number 1
Issue number 3
Start page 291
End page 297
Total pages 7
Publisher Elsevier Science B.V.
Place of publication Amsterdamn, Netherlands
Publication date 2009-07
ISSN 1756-4646
Keyword(s) chromium (III)-omega-3 complex
mass spectrometry
Summary Supplements containing chromium in its trivalent oxidation state [Cr(III)] are used by diabetic patients to improve their glucose and insulin levels and omega-3 fatty acids are also beneficial for people with insulin resistance or diabetes. It seemed very useful to combine chromium(III) and omega-3 functional entities into single molecules. Here we synthesized and characterized a chromium cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) complex, one of the two main components of the heterogeneous chromium(III) fish oil omega-3 concentrate products. Ethyl cis-4,7,10,13,16,19-docosahexaenoate was hydrolyzed with sodium hydroxide, and the generated salt was reacted in situ with chromium(III) chloride hexahydrate and converted into an oxo-centred trinuclear chromium(III) complex. A study of the DHA–chromium(III) complex by liquid chromatography/tandem mass spectrometry/(LC/MS/MS) is reported in this work. The data suggest a triaqua-μ3-oxohexakis-μ-docosahexaenoatotrichromium(1+), [Cr3O(C22H31O2)6(H2O)3]+, core structure.
Language eng
DOI 10.1016/j.jff.2009.06.001
Field of Research 090802 Food Engineering
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Elsevier
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Document type: Journal Article
Collection: School of Life and Environmental Sciences
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