Chromium(III)-docosahexaenoic acid complex : synthesis and characterization

Kralovec, Jaroslav A., Potvin, Michael A., Wright, Jeffrey H. D., Watson, Lynn V., Ewart, H. Stephen, Curtis, Jonathan M. and Barrow, Colin J. 2009, Chromium(III)-docosahexaenoic acid complex : synthesis and characterization, Journal of functional foods, vol. 1, no. 3, pp. 291-297.

Attached Files
Name Description MIMEType Size Downloads

Title Chromium(III)-docosahexaenoic acid complex : synthesis and characterization
Author(s) Kralovec, Jaroslav A.
Potvin, Michael A.
Wright, Jeffrey H. D.
Watson, Lynn V.
Ewart, H. Stephen
Curtis, Jonathan M.
Barrow, Colin J.
Journal name Journal of functional foods
Volume number 1
Issue number 3
Start page 291
End page 297
Total pages 7
Publisher Elsevier Science B.V.
Place of publication Amsterdamn, Netherlands
Publication date 2009-07
ISSN 1756-4646
Keyword(s) chromium (III)-omega-3 complex
diabetes
synthesis
mass spectrometry
Summary Supplements containing chromium in its trivalent oxidation state [Cr(III)] are used by diabetic patients to improve their glucose and insulin levels and omega-3 fatty acids are also beneficial for people with insulin resistance or diabetes. It seemed very useful to combine chromium(III) and omega-3 functional entities into single molecules. Here we synthesized and characterized a chromium cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) complex, one of the two main components of the heterogeneous chromium(III) fish oil omega-3 concentrate products. Ethyl cis-4,7,10,13,16,19-docosahexaenoate was hydrolyzed with sodium hydroxide, and the generated salt was reacted in situ with chromium(III) chloride hexahydrate and converted into an oxo-centred trinuclear chromium(III) complex. A study of the DHA–chromium(III) complex by liquid chromatography/tandem mass spectrometry/(LC/MS/MS) is reported in this work. The data suggest a triaqua-μ3-oxohexakis-μ-docosahexaenoatotrichromium(1+), [Cr3O(C22H31O2)6(H2O)3]+, core structure.
Language eng
Field of Research 090802 Food Engineering
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019970

Document type: Journal Article
Collection: School of Life and Environmental Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in TR Web of Science
Scopus Citation Count Cited 1 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 349 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Mon, 28 Sep 2009, 16:42:04 EST by Teresa Treffry

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.