Chemiluminescence as a screening tool for bioactive phytochemicals

McDermott, Geoffrey P., Conlan, Xavier A., Stupka, Nicole, Francis, Paul S. and Barnett, Neil W. 2009, Chemiluminescence as a screening tool for bioactive phytochemicals, in 42nd IUPAC Congress, International Union of Pure and Applied Chemistry, Research Triangle Park, N.C..


Title Chemiluminescence as a screening tool for bioactive phytochemicals
Author(s) McDermott, Geoffrey P.
Conlan, Xavier A.
Stupka, Nicole
Francis, Paul S.
Barnett, Neil W.
Conference name IUPAC Congress : Chemistry Solutions (42nd : 2009 : Glasgow, U.K.)
Conference location Glasgow, U.K.
Conference dates 2 - 7 August 2009
Title of proceedings 42nd IUPAC Congress
Publication date 2009
Publisher International Union of Pure and Applied Chemistry
Place of publication Research Triangle Park, N.C.
Summary

The health benefits of antioxidant-rich ‘Mediterranean’ type diets high in grain, olives and red wine are well recognised. Since these foodstuffs consist of a complex matrix of chemical components, to date, the primary challenge lies in prioritising and isolating molecules for a physiologically relevant cell culture assay to assess their human health benefits. Currently, the most common approach requires arduous sample fractionation into smaller ‘crude’ extracts, followed by costly cell culture assays, with the bioactive identified only after a positive response in the cell. The work presented within this poster demonstrates the potential for an acidified potassium permanganate chemiluminescence detector as a much simpler screening tool to identify the best bioactive candidates from a complex sample matrix.

Language eng
Field of Research 060110 Receptors and Membrane Biology
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category E3 Extract of paper
HERDC collection year 2009
Persistent URL http://hdl.handle.net/10536/DRO/DU:30019988

Document type: Conference Paper
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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Created: Mon, 28 Sep 2009, 18:11:01 EST by Nicole Stupka

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